Results 91 to 100 of about 1,827,838 (293)

Penilaian kebersihan dinding sepertiga apikal saluran akar dari smear layer menggunakan hand use dan rotary instrument design convex triangular cross section dengan rotary instrument design rectangular cross section

, 2015
penelitian ini bertujuan ingin menilai perbedaan kebersihan dinding sepertiga apikal saluran akar dari smear layer antara preparasi menggunakan hand use instrumen desing convex triangular cross section,rotary instrument design rectangular cross section ...
Nur amda
core  

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Enhancing Quasi‐Two‐Dimensional Electronic Structure in Bi2O2Se via Chlorine Substitution

Advanced Science, EarlyView.
We demonstrate chlorine substitution as an effective strategy to transform Bi2O2Se into an exfoliatable van der Waals superlattice. Key electronic band feature, including indirect bandgap, effective mass is well preserved, while the 2D character of the system is sufficiently enhanced.
Yong‐Zhen Jiang, Qi‐Xun Wen, Xiang Xu, Su‐Tao Sun, Feng‐Fan Ren, Zi‐Xuan Zhou, Xing‐Yuan You, Yu‐Cheng Kan, Zheng Zhang, Jie‐Yi Liu, Yu‐Zhou Zhao, Zheng‐Tai Liu, Mao Ye, Shu‐Hua Yao, Jian Zhou, Yan‐Bin Chen, Zhong‐Kai Liu, Yu‐Lin Chen, Yang‐Yang Lv, Cheng Chen   +19 more
wiley   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Machine Learning Potential for Calcium Silicate Hydrates With Broad Compositional and Structural Diversity

Advanced Science, EarlyView.
Existing machine learning potentials remain limited in their ability to generalize across the broad chemical and structural variability of C–S–H. Here, a representative DFT‐labeled dataset is constructed through large‐scale model generation, redundancy‐controlled screening, first‐principles optimization, and targeted sampling of non‐equilibrium ...
Yunjian Li, Cheng Chen, Roland J.‐M. Pellenq, Zongjin Li, Jiaping Liu   +4 more
wiley   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

A scanning electron microscope (SEM) study of the smear layer in root canals. [PDF]

, 1990
A Scanning Electron Microscope was used to study the so-called "smear layer" produced in biomechanically prepared root canals. Fine, freshly-extracted incisors were used and the canals instrumented with K-type files and irrigated with 5% NaOCI ...

core   +1 more source

Data‐Driven and Physics‐Informed Modeling Perspectives for Soft Manipulators: From SINDy to Hybrid Intelligence

Advanced Science, EarlyView.
This Perspective charts the modeling landscape for soft manipulators, spanning sparse system identification, neural dynamics, physics‐informed models and hybrid intelligence. We examine how physics, data, sensing, adaptation and control can assume complementary roles within this landscape, and provide a framework for selecting modeling approaches ...
Wenbo Hui, Yunyi Wang, Teng Zhang, Yang Chen, Min Pan   +4 more
wiley   +1 more source

Spatiotemporal Computational Meta‐Imager for Broadband Dual‐Layer Optical Convolution

Advanced Science, EarlyView.
A single‐layer polarization‐multiplexed meta‐imager achieves factorized dual‐layer broadband convolution via spatiotemporal kernel decomposition. Fixed Bessel‐vortex bases and time‐sequential liquid‐crystal modulation deliver tunable signed weights and in‐situ fabrication‐error compensation. Experiments verify improved classification performance across
Mengguang Wang, Chenglong Zheng, Huaping Zang, Changwei Zhang, Huai Xia, Chang Wang, Zhenrong Zheng   +6 more
wiley   +1 more source

Probe‐Free, Primer‐Programmed Amplicon Encoding Enables Nanopore‐Based Multiplex Detection With Deep Learning Decoding

Advanced Science, EarlyView.
Primer‐programmed amplicon encoding enables reporter‐probe‐free multiplex nucleic acid identification using glass nanopore sensing and deep neural network decoding. ABSTRACT Single‐reaction multiplex nucleic acid testing (NATs) must both co‐amplify multiple targets and distinguish the resulting amplicons within the product mixture.
Md. Ahasan Ahamed, Muhammad Asad Ullah Khalid, Wahid Uz Zaman, Anthony J. Politza, Weihua Guan   +4 more
wiley   +1 more source