Results 1 to 10 of about 9,361 (152)

Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs. [PDF]

Nucleic Acids Res, 2012
Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use ...
Makarov EM, Owen N, Bottrill A, Makarova OV.   +3 more
europepmc   +8 more sources

Diverse expression of selected SMN complex proteins in humans with sporadic amyotrophic lateral sclerosis and in a transgenic rat model of familial form of the disease. [PDF]

PLoS One, 2014
There is circumstantial evidence linking sporadic amyotrophic lateral sclerosis (ALS) cases to a malfunction or deficit of a multimeric SMN complex that scrutinizes cellular RNAs; the core of this complex is survival motor neuron (SMN, or gemin 1) protein.
Rafałowska J, Sulejczak D, Chrapusta SJ, Gadamski R, Dziewulska D.   +4 more
europepmc   +6 more sources

The Gemin5 Protein of the SMN Complex Identifies snRNAs [PDF]

Molecular Cell, 2006
The survival of motor neurons protein (SMN) is part of a large complex that contains six other proteins, Gemins2-7. The SMN complex assembles the heptameric Sm protein core on small nuclear RNAs (snRNAs) and plays a critical role in the biogenesis of snRNPs, the major and essential components of mRNA splicing in eukaryotes.
Francesco Lotti, Hongying Deng, Daniel J. Battle, Lili Wan, Gideon Dreyfuss, Chi-Kong Lau   +5 more
openaire   +3 more sources

Gemin5, a Novel WD Repeat Protein Component of the SMN Complex That Binds Sm Proteins [PDF]

Journal of Biological Chemistry, 2002
The survival of motor neurons (SMN) protein is the product of the disease gene of spinal muscular atrophy and is found both in the cytoplasm and the nucleus, where it is concentrated in gems. SMN is part of a multi-protein complex that includes Gemin2, Gemin3, and Gemin4.
Zissimos Mourelatos, Zissimos Mourelatos, Gideon Dreyfuss, Linda Abel, Matthias Mann, Amelie K. Gubitz, Juri Rappsilber   +6 more
openaire   +4 more sources

Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein [PDF]

Nucleic Acids Research, 2001
In previous studies we showed that galectin-1 and galectin-3 are factors required for the splicing of pre-mRNA, as assayed in a cell-free system. Using a yeast two-hybrid screen with galectin-1 as bait, Gemin4 was identified as a putative interacting protein.
Sharon Grabski, Ronald J. Patterson, Patricia G. Voss, Jung Woo Park, John L. Wang   +4 more
openaire   +3 more sources

Friend of Prmt1, FOP is a novel component of the nuclear SMN complex isolated using biotin affinity purification [PDF]

, 2014
SMN (survival motor neuron protein) complexes are essential for the biogenesis of uridine-rich small nuclear ribonucleoproteins (UsnRNPs). During the biogenesis, the SMN complexes bound to UsnRNPs are transported from the cytoplasm to the nucleus, and ...
Ishikawa, H. (Hiroki), Isobe, T. (Toshiaki), Izumikawa, K. (Keiichi), Miyazawa, N. (Naoki), Nakayama, H. (Hiroshi), Nobe, Y. (Yuko), Philipsen, J.N.J. (Sjaak), Takahashi, N. (Nozomi), Taoka, M. (Masato), Terukina, G. (Goro), Yamauchi, N. (Naoto), Yoshikawa, H. (Harunori)   +11 more
core   +6 more sources

FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA [PDF]

, 2012
SummaryMutations in the RNA binding protein FUS cause amyotrophic lateral sclerosis (ALS), a fatal adult motor neuron disease. Decreased expression of SMN causes the fatal childhood motor neuron disorder spinal muscular atrophy (SMA).
Battle, Boillée, Bosco, Coovert, Da Cruz, Das, DeJesus-Hernandez, Dormann, Fallini, Fallini, Gertz, Gitcho, Gubitz, Kabashi, Kabashi, Kariya, Kim, Kwiatkowski, Lefebvre, Ling, Liu, Liu-Yesucevitz, Renton, Sephton, Shan, Sreedharan, Valdmanis, Vance, Waibel, Wang, Yong   +30 more
core   +4 more sources

A role for protein phosphatase PP1γ in SMN complex formation and subnuclear localization to Cajal bodies [PDF]

Journal of Cell Science, 2012
The spinal muscular atrophy (SMA) gene product SMN forms with Gemin2 to 8 and unrip the ubiquitous SMN complex that is required for the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), their nuclear import and localization to subnuclear domain Cajal bodies (CBs). The concentration of the SMN complex and snRNPs in CBs are reduced upon
Renvoisé, B. (Benoît), Quérol, G. (Gwendoline), Verrier, E. (Eloi), Burlet, P. (Philippe), Lefebvre, S. (Suzie)   +4 more
openaire   +5 more sources

SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation [PDF]

Nucleic Acids Research, 2017
Selenoprotein synthesis requires the co-translational recoding of a UGASec codon. This process involves an RNA structural element, called Selenocysteine Insertion Sequence (SECIS) and the SECIS binding protein 2 (SBP2). Several selenoprotein mRNAs undergo unusual cap hypermethylation by the trimethylguanosine synthase 1 (Tgs1), which is recruited by ...
Anne-Sophie Gribling-Burrer, Michael Leichter, Laurence Wurth, Alexandra Huttin, Florence Schlotter, Nathalie Troffer-Charlier, Vincent Cura, Martine Barkats, Jean Cavarelli, Séverine Massenet, Christine Allmang   +10 more
openaire   +5 more sources

NUFIP and the HSP90/R2TP chaperone bind the SMN complex and facilitate assembly of U4-specific proteins [PDF]

Nucleic Acids Research, 2015
The Sm proteins are loaded on snRNAs by the SMN complex, but how snRNP-specific proteins are assembled remains poorly characterized. U4 snRNP and box C/D snoRNPs have structural similarities. They both contain the 15.5K and proteins with NOP domains (PRP31 for U4, NOP56/58 for snoRNPs).
Bizarro, Jonathan, Dodre, Maxime, Huttin, Alexandra, Charpentier, Bruno, Schlotter, Florence, Branlant, Christiane, Verheggen, Céline, Massenet, Severine, Bertrand, Edouard   +8 more
openaire   +4 more sources