Results 51 to 60 of about 9,361 (152)

Genetic Architecture of Immune Cell DNA Methylation in the Rhesus Macaque

Molecular Ecology, EarlyView.
ABSTRACT Genetic variation that impacts gene regulation, rather than protein function, can have strong effects on trait variation both within and between species. Epigenetic mechanisms, such as DNA methylation, are often an important intermediate link between genotype and phenotype, yet genetic effects on DNA methylation remain understudied in natural ...
Christina E. Costa, Marina M. Watowich, Elisabeth A. Goldman, Kirstin N. Sterner, Josue E. Negron‐Del Valle, Daniel Phillips, Cayo Biobank Research Unit, Michael L. Platt, Michael J. Montague, Lauren J. N. Brent, James P. Higham, Noah Snyder‐Mackler, Amanda J. Lea   +12 more
wiley   +1 more source

Genetic Circuitry of Survival Motor Neuron, the Gene Underlying Spinal Muscular Atrophy [PDF]

, 2013
The clinical severity of the neurodegenerative disorder spinal muscular atrophy (SMA) is dependent on the levels of functional Survival Motor Neuron (SMN) protein.
Artavanis-Tsakonas, Spyros, Brachat, Sophie, Curtis, Daniel, Davidow, Lance Steven, Dimlich, Douglas, Guruharsha, K. G., Hart, Anne C., Hori, Kazuya, Kankel, Mark William, Loureiro, Joseph, Richardson, Delwood, Rubin, Lee, Sen, Anindya, Sivasankaran, Rajeev, Van Vactor, David L., Yokokura, Takakazu   +15 more
core   +1 more source

Alternative Splicing Regulation in Metabolic Disorders

Obesity Reviews, EarlyView.
ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley   +1 more source

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers [PDF]

, 2017
Small molecule splicing modifiers have been previously described that target the general splicing machinery and thus have low specificity for individual genes. Several potent molecules correcting the splicing deficit of the SMN2 (survival of motor neuron
Allain, F. H., Augustin, A., Banfai, B., Berntenis, N., Birrer, P., Campagne, S., Clery, A., Duran-Pacheco, G., Ebeling, M., Giroud, N., Golling, S., Heckel, T., Hsiu Liu, Y., Huber, S., Hug, M. N., Khawaja, S., Krainer, A. R., Lamerz, J., Luebbers, T., McCarthy, K. D., Meier, S., Meistermann, H., Metzger, F., Moursy, A., Paushkin, S., Ratni, H., Schmucki, R., Sivaramakrishnan, M., Tzouros, M.   +28 more
core   +1 more source

Drought affects Fe deficiency‐induced responses in a purple durum wheat (Triticum turgidum subsp. durum) genotype

Plant Biology, EarlyView.
Combined Fe deficiency and drought in durum wheat trigger interactive responses: drought suppressed root Fe uptake regardless of Fe availability, and both stresses altered phytosiderophore release, ABA level and Fe transporter gene expression, revealing a trade‐off between water and Fe. Abstract Iron (Fe) is essential for plants and humans, with over 2
G. Quagliata, M. D. G. Molina, G. Mannino, E. Coppa, M. N. Saidi, S. Palombieri, F. Sestili, G. Vigani, S. Astolfi   +8 more
wiley   +1 more source

Influence of Exercise Heat Acclimation Protocol Characteristics on Adaptation Kinetics: A Quantitative Review With Bayesian Meta‐Regressions

Comprehensive Physiology, Volume 15, Issue 3, June 2025.
ABSTRACT The integrative influence of heat acclimation (HA) protocol characteristics and approach on adaptation kinetics and exercise capacity/performance in the heat remains unclear. Bayesian multilevel regression models were used to estimate adaptations with the number of exposures, exposure duration, ambient temperature, water vapor pressure, and HA
Peter McDonald, Harry A. Brown, Thomas H. Topham, Monica K. Kelly, William T. Jardine, Amelia Carr, Michael N. Sawka, Andrew P. Woodward, Brad Clark, Julien D. Périard   +9 more
wiley   +1 more source

Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]

, 2019
Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D., Mosley, Amber L., Peck, Sarah A., Victorino, Jose F.   +3 more
core   +1 more source

Advancing Sustainability in Fruit and Vegetable Packaging: The Role of Nanotechnology in Food Preservation

eFood, Volume 6, Issue 3, June 2025.
This article examines the significant role of nanotechnology in revolutionizing fruit and vegetable packaging, focusing on its capacity to enhance sustainability and food preservation. By utilizing nanoparticles and innovative packaging solutions, we highlight how nanotechnology improves barrier properties, implements antimicrobial measures, and ...
Farhang Hameed Awlqadr, Ammar B. Altemimi, Ali Muhi Aldeen Omar, Mohammed N. Saeed, Syamand Ahmed Qadir, Aryan Mahmood Faraj, Alaa Jabbar Abd Al‐Manhel, Tablo H. Salih, Mohammad Ali Hesarinejad, Italo Rennan Sousa Vieira   +9 more
wiley   +1 more source

Transcriptomic comparison of Drosophila snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy [PDF]

, 2016
Survival motor neuron (SMN) functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs) that catalyze pre-mRNA splicing. Here, we used disruptions in Smn and two additional snRNP biogenesis genes, Phax and Ars2, to classify RNA ...
Garcia, Eric L., Matera, A. Gregory, Praveen, Kavita, Wen, Ying   +3 more
core   +3 more sources

Elucidating Development Trajectories of Brain Functional Abnormalities in Major Depressive Disorder Utilizing a Data‐Driven Disease Progression Model

Human Brain Mapping, Volume 46, Issue 8, June 1, 2025.
Major depressive disorder exhibits profound phenotypic and temporal heterogeneity. This study aims to identify distinct brain change trajectories in MDD using the subtype and stage inference model to deepen our understanding of heterogeneity, as well as to compare the cognitive function change patterns among subtypes with different trajectories ...
Yuhong Zheng, Peng Wang, Chi Yao, Jinghua Wang, Jinhui Wang, Shao‐Wei Xue   +5 more
wiley   +1 more source