Results 71 to 80 of about 5,400 (185)

Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22

Disease Models & Mechanisms, 2017
Unique deficits in the function of adult sensory neurons as part of their early neurodegeneration might account for progressive polyneuropathy during chronic diabetes mellitus.
Masaki Kobayashi, Ambika Chandrasekhar, Chu Cheng, Jose A. Martinez, Hilarie Ng, Cristiane de la Hoz, Douglas W. Zochodne   +6 more
doaj   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

The Illness Narratives of Children and Young People With Spinal Muscular Atrophy: A Scoping Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim(s) This review seeks to explore the illness narratives of children and young people focusing on their healthcare trajectories; the right to health; and the kind of stories told about them. Design This scoping review adopts a narrative approach to analyse how the illness experience of Spinal Muscular Atrophy is represented in the literature,
Marcela González‐Agüero, Constanza Quezada, Valentina Turén, Josefa Camelio, Martina De Filippi, Caroline Bradbury‐Jones, Julie Taylor   +6 more
wiley   +1 more source

The variability of giraffe skull morphology

Journal of Anatomy, EarlyView.
What does giraffe skull shape tell us about their development and evolution? Abstract Giraffe (Giraffa spp.) are among the most unique and charismatic extant animals, largely due to their distinct morphology. The evolutionary and developmental origin of ossicones is a key factor in giraffid biology, yet other features building their characteristic head
Nikolaos Kargopoulos, Jesús Marugán‐Lobón, Anusuya Chinsamy‐Turan, Bernard R. Agwanda, Michael Butler Brown, Stephanie Fennessy, Sara Ferguson, Rigardt Hoffman, Fredrick Lala, Arthur Muneza, Ogeto Mwebi, Moses Otiende, Alice Petzold, Sven Winter, Abdoul Razack Moussa Zabeirou, Julian Fennessy   +15 more
wiley   +1 more source

Development of Therapies for Spinal Muscular Atrophy Using Gene Therapy and Nanotechnology [PDF]

, 2013
Spinal muscular atrophy (SMA) is a genetic disease which is characterized by muscle weakness and atrophy. The disease arises from mutations in the survival motor neuron 1 (SMN1) gene causing degeneration of spinal cord motor neurons.
Little, Daniel
core  

The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1

, 2001
Background: The survival of motor neurons (SMN) protein is the protein product of the spinal muscular atrophy (SMA) disease gene. SMN and its associated proteins Gemin2, Gemin3, and Gemin4 form a large complex that plays a role in snRNP assembly, pre ...
Dreyfuss, Gideon, Pellizzoni, Livio, Livio Pellizzoni, Jennifer Baccon, Bernard Charroux, Gideon Dreyfuss, Charroux, Bernard, Baccon, Jennifer   +7 more
core   +1 more source

Oligomerization regulates the interaction of Gemin5 with members of the SMN complex and the translation machinery

Cell Death Discovery
RNA-binding proteins are multifunctional molecules impacting on multiple steps of gene regulation. Gemin5 was initially identified as a member of the survival of motor neurons (SMN) complex.
Rosario Francisco-Velilla, Salvador Abellan, Azman Embarc-Buh, Encarnacion Martinez-Salas   +3 more
doaj   +1 more source

Cellular immune response of Amblyomma sculptum and Amblyomma americanum to entomopathogenic fungi: Implications for biological tick control

Medical and Veterinary Entomology, EarlyView.
Amblyomma sculptum showed a plasmatocyte‐dominant haemocyte profile. Beauveria bassiana increased plasmatocytes and reduced granulocytes, whereas Metarhizium robertsii did not cause significant changes. Amblyomma americanum showed a granulocyte‐dominant haemocyte profile. Beauveria bassiana reduced total haemocytes and granulocytes. B.
Cárita de Souza Ribeiro‐Silva, Valesca Henrique Lima, Salorrane Miranda N. Pinto, Gustavo Felizardo S. Sandes, Victor Hugo Ribeiro Costa, Albert Mulenga, Adela S. Oliva Chavez, Éverton Kort Kamp Fernandes   +7 more
wiley   +1 more source

Perioperative Management for Patients With Spinal Muscular Atrophy Undergoing Scoliosis Surgery: A Single‐Center Retrospective Study

Orthopaedic Surgery, EarlyView.
This largest Asian case series confirms that posterior spinal fusion for SMA scoliosis is safe and effective despite severe deformity and markedly impaired pulmonary function. Meticulous multidisciplinary care, including advanced airway planning, hemodynamic support, blood management, and proactive electrolyte correction, is critical to optimizing ...
Ai Hu, Xiuhua Zhang, Lulu Ma, Haisong Lu, Yulei Dong, Weiyun Chen, Yuguang Huang, Jianxiong Shen   +7 more
wiley   +1 more source