Results 81 to 90 of about 5,400 (185)

Drought affects Fe deficiency‐induced responses in a purple durum wheat (Triticum turgidum subsp. durum) genotype

Plant Biology, EarlyView.
Combined Fe deficiency and drought in durum wheat trigger interactive responses: drought suppressed root Fe uptake regardless of Fe availability, and both stresses altered phytosiderophore release, ABA level and Fe transporter gene expression, revealing a trade‐off between water and Fe. Abstract Iron (Fe) is essential for plants and humans, with over 2
G. Quagliata, M. D. G. Molina, G. Mannino, E. Coppa, M. N. Saidi, S. Palombieri, F. Sestili, G. Vigani, S. Astolfi   +8 more
wiley   +1 more source

Structural basis of ligand selectivity in FAD/NAD(P)H‐dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase

Protein Science, Volume 35, Issue 7, July 2026.
Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Giulia Chiara Maria Perrone, Serena Spadone, Anna Lucia Francavilla, Sara Morselli, Sabino Todisco, Margherita Ortalli, Jairo Alfonso Mendoza‐Roldan, Valeria Scaglione, Maria Noemi Sgobba, Lorenzo Guerra, Federica Belluti, Stefania Varani, Domenico Otranto, Anna De Grassi, Mariateresa Volpicella, Ciro Leonardo Pierri   +15 more
wiley   +1 more source

The Molecular Diagnosis of Myopathies: Integrating Genomic, Proteomic, and Pathological Insights Toward Precision Medicine

Clinical Genetics, Volume 110, Issue 1, Page 15-28, July 2026.
Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem, Denise de Abreu Pereira, Katia Carneiro   +2 more
wiley   +1 more source

Proteomic analysis of the SMN complex reveals conserved and etiologic connections to the proteostasis network

Frontiers in RNA Research
IntroductionMolecular chaperones and co-chaperones are highly conserved cellular components that perform a variety of duties related to the proper three-dimensional folding of the proteome.
A. Gregory Matera, A. Gregory Matera, A. Gregory Matera, Rebecca E. Steiner, C. Allie Mills, Benjamin D. McMichael, Laura E. Herring, Eric L. Garcia, Eric L. Garcia   +8 more
doaj   +1 more source

Role of the SMN complex in snRNP biogenesis [PDF]

Small nuclear ribonucleoprotein particles (snRNPs) are an essential component of the spliceosome, a dynamic protein complex that mediates RNA splicing. These particles are composed of a single small nuclear RNA, from which they take their name, a ring of
Hanušková, Klára
core   +1 more source

Multifunctionality of annual forage crop mixtures for improved biomass, beef cattle diets, and soil health outcomes

Agrosystems, Geosciences &Environment, Volume 9, Issue 2, June 2026.
Abstract Cover crop mixtures (CCMs) can fit well into various agricultural production systems and have gained popularity among grain and livestock producers, as well as organic and market gardeners across western Canada, due to their potential to enhance forage production and soil health.
Akim Tunde Omokanye, Surendra Bhattarai, Guillermo Hernandez Ramirez, Blasius Azuhnwi, Yamily Zavala, Hayford Gyamfi, Bharat Shrestha   +6 more
wiley   +1 more source

A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II [PDF]

, 2014
Cajal bodies are nuclear structures that are involved in biogenesis of snRNPs and snoRNPs, maintenance of telomeres and processing of histone mRNA. Recently, the SUMO isopeptidase USPL1 was identified as a component of Cajal bodies that is essential for ...
Winter, Ulrike, Hutten, Saskia, Melchior, Frauke, Chachami, Georgia, Lamond, Angus I.; id_orcid   +4 more
core   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1552-1566, June 2026.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Beyond mammals: the evolution of chewing and other forms of oropharyngeal food processing in vertebrates

Biological Reviews, Volume 101, Issue 3, Page 1406-1462, June 2026.
ABSTRACT Oropharyngeal food processing exhibits a remarkable diversity among vertebrates, reflecting the evolution of specialised ‘processing centres’ associated with the mandibular, hyoid, and branchial arches. Although studies have detailed various food‐processing strategies and mechanisms across vertebrates, a coherent and comprehensive terminology ...
Daniel Schwarz, Maja Mielke, Stephan Handschuh, Anthony Herrel, Patrick Lemell, Léa Da Cunha, Nicolai Konow   +6 more
wiley   +1 more source

hnRNP R regulates mitochondrial movement and membrane potential in axons of motoneurons

Neurobiology of Disease
Axonal mitochondria defects are early events in the pathogenesis of motoneuron disorders such as spinal muscular atrophy and amyotrophic lateral sclerosis.
Sophia Dithmar, Abdolhossein Zare, Saeede Salehi, Michael Briese, Michael Sendtner   +4 more
doaj   +1 more source