Results 101 to 110 of about 5,400 (185)
MicrobiologyOpen, Volume 15, Issue 3, June 2026.Multidrug‐resistance (MDR) Enterobacter cloacae was targeted using a genome wide immunoinformatics approach. Conserved and surface exposed outer membrane protien A (OmpA) was identified as the prime vaccine target following proteome screening, antigenicity, allergenicity, and homology analysis.
Maha A. Aljumaa +3 more
wiley +1 more source
Structural and biochemical studies of the Gemin6/7 heterodimer from the human SMN complex
, 2005 The survival of motor neurons (SMN) protein, product of the disease gene of the common neurodegenerative disease spinal muscular atrophy (SMA), is part of a large multi-protein complex (SMN complex) that also contains Gemins2–7. The SMN complex functions
Ma, Yingli
core
SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain
, 2008 Spinal muscular atrophy (SMA) is a recessive neuromuscular disease caused by mutations in the human survival motor neuron 1 (SMN1) gene.
Fuentes, Jennifer L. +5 more
core +1 more source
A unique mechanism of snRNP core assembly
Nature CommunicationsThe assembly of most spliceosomal snRNP cores involves seven Sm proteins (D1/D2/F/E/G/D3/B) forming a ring around snRNA, typically requiring essential assembly chaperones like the SMN complex, associated with spinal muscular atrophy (SMA). Strikingly, in
Yingzhi Wang +12 more
doaj +1 more source
Alternative splicing events driven by altered levels of GEMIN5 undergo translation
RNA BiologyGEMIN5 is a multifunctional protein involved in various aspects of RNA biology, including biogenesis of snRNPs and translation control. Reduced levels of GEMIN5 confer a differential translation to selective groups of mRNAs, and biallelic variants ...
Rosario Francisco-Velilla +4 more
doaj +1 more source
The Long Haul: Microtubule Motors as the Essential Supply Line for Neuronal Longevity
Journal of Neurochemistry, Volume 170, Issue 6, June 2026.To survive a lifetime, neurons depend on a high‐fidelity logistics network powered by microtubule motors. We explore how a broad spectrum of genetic defects in this machinery drive a devastating spectrum of neurodevelopmental and neurodegenerative diseases, including Hereditary Spastic Paraplegia (HSP), Charcot–Marie‐Tooth Type 2 (CMT2), and ...
Emma D. Turner, Alison E. Twelvetrees
wiley +1 more source
, 2005 Spliceosomal Uridine-rich small ribonucleo protein (U snRNP) assembly is an active process mediated by the macromolecular survival motor neuron (SMN) complex. This complex contains the SMN protein and six additional proteins, named Gemin2–7, according to
Müller, F. +11 more
core +1 more source
The Chronicles of X-Linked Spinal Muscular Atrophy: The Linkage, The Gene and The SMN Complex
, 2008 Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease. SMA is associated with homozygous mutations in the Survival of Motor Neuron gene I (SMN1).
Yariz, Kemal
core +1 more source
Lymphotropic Herpesvirus saimiri Uses the SMN Complex To Assemble Sm Cores on Its Small RNAs
, 2004 The lymphotropic Herpesvirus saimiri (HVS) causes acute leukemia, T-cell lymphoma, and death in New World monkeys. HVS encodes seven small RNAs (HSURs) of unknown function.
Tracey J. Golembe +5 more
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Gemin4: a novel component of the SMN complex that is found in both gems and nucleoli
, 2000 The survival of motor neurons (SMN) pro-tein, the product of the neurodegenerative disease spi-nal muscular atrophy (SMA) gene, is localized both in the cytoplasm and in discrete nuclear bodies called gems.
Andrej Shevchenko +6 more
core