Results 111 to 120 of about 5,400 (185)

SMN - A chaperone for nuclear RNP social occasions?

, 2017
Survival Motor Neuron (SMN) protein localizes to both the nucleus and the cytoplasm. Cytoplasmic SMN is diffusely localized in large oligomeric complexes with core member proteins, called Gemins.
Raimer, Amanda C., Gray, Kelsey M., Matera, A. Gregory   +2 more
core   +1 more source

Characterization of SMN and Gemin2: Insights into Spinal Muscular Atrophy [PDF]

, 2012
: Spinal muscular atrophy (SMA) is a neurodegenerative disease that results in the loss of lower body muscle function. SMA is the second leading genetic cause of death in infants and arises from the loss of the Survival of Motor Neuron (SMN) protein. SMN

core  

RNA -protein interactions of the survival of motor neurons (SMN) complex and the implications for snRNP assembly

, 2005
Pre-mRNA splicing is mediated by the spliceosome whose catalytic core is formed from uridine-rich small nuclear ribonucleoprotein particles (U snRNPs). Each of the major U snRNPs contains a small nuclear RNA (snRNA) and a set of seven common Sm proteins ...
Polsky, Tracey Golembe
core  

The Gemin2 Complex: An Evolving View of SMN Mediated snRNP Assembly

, 2017
Assembly of spliceosome snRNPs requires a megadalton molecular machine called the survival of motor neuron (SMN) complex. In higher eukaryotes, this complex consists of SMN, Gemins2-8 and unrip.
Babiash, Eric Steven, Babiash, Eric S
core  

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Assisted RNP assembly: SMN and PRMT5 complexes cooperate in the formation of spliceosomal UsnRNPs

, 2002
Although spliceosomal Sm proteins can assemble spontaneously onto UsnRNA in vitro, this process requires assisting factors in vivo. SMN, the protein involved in spinal muscular atrophy, is part of a complex that contains the Sm proteins and serves as a ...
Fischer, U., Meister, G.
core  

A stand-alone ICln release module revealed by deconstructing the SMN complex with engineered Brr1. [PDF]

Nucleic Acids Res
Hu Y, Zhang J, Xu B, Wang Y, Mu L, Zhang R.   +5 more
europepmc   +1 more source

Symposia

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Function of the Survival of Motor Neuron (SMN) complex in the biogenesis of RNA/protein particles

, 2008
L’amyotrophie spinale (SMA) est causée par une réduction du taux de la protéine de Survie des MotoNeurones (SMN). Cette protéine est associée aux protéines Gemin 2 à Gemin 8 et unrip pour former le complexe SMN.
Piazzon, Nathalie
core  

Neurodegenerative spliceosomopathies. [PDF]

Front Cell Dev Biol
Mavillonio A, Rizzini D, Detassis S, Denti MA.   +3 more
europepmc   +1 more source