Results 111 to 120 of about 10,068 (192)
Ligand‐driven modulation of chaperone–cochaperone networks shapes proteostasis outcomes
Protein Science, Volume 35, Issue 5, May 2026.Abstract Protein homeostasis depends on a delicate interplay between folding and degradation, orchestrated by molecular chaperones. Among them, Hsp90 is a central hub, regulating nearly 10% of the proteome through ATP‐driven conformational cycles and selective interactions with cochaperones.
Andrea Magni +9 more
wiley +1 more source
hnRNP R regulates mitochondrial movement and membrane potential in axons of motoneurons
Neurobiology of DiseaseAxonal mitochondria defects are early events in the pathogenesis of motoneuron disorders such as spinal muscular atrophy and amyotrophic lateral sclerosis.
Sophia Dithmar +4 more
doaj +1 more source
Integrated genomic and transcriptomic analyses of radiation-induced malignancies [PDF]
, 2016 Cancer is a genetic disease caused by an unregulated expansion of a clone of cells (Sompayrac, 2004). The genetic abnormalities in cancer are the consequences of defective DNA replication, repair, maintenance, and modification, genetic background, and ...
Lee, Yong Eun
core +1 more source
Spinal muscular atrophy: Factors that modulate motor neurone vulnerability. [PDF]
, 2017 Spinal muscular atrophy (SMA), a leading genetic cause of infant death, is a neurodegenerative disease characterised by the selective loss of particular groups of motor neurones in the anterior horn of the spinal cord with concomitant muscle weakness. To
Heath, P.R. +3 more
core +1 more source
Perspectives for Advancing Biotechnological Succinic Acid Production
Microbial Biotechnology, Volume 19, Issue 5, May 2026.Succinic acid is an important molecule for sustainable chemical manufacturing, but its industrial production faces high costs and sustainability challenges, which are linked to feedstocks and excessive acid/base consumption. This opinion explores production routes based on next‐generation feedstocks and low‐pH fermentations to inspire novel cost ...
Christoph Gunkel, Bastian Blombach
wiley +1 more source
Optimizing Oligonucleotide Therapeutics: A Model‐Informed Drug Development Perspective
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Oligonucleotide therapies have emerged as a powerful therapeutic class, providing novel solutions for diverse diseases through antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers that specifically target and modulate gene expression or protein function. However, oligonucleotide development faces distinct challenges,
Ye Yuan +7 more
wiley +1 more source
Effect of Non-Coding RNA on Post-Transcriptional Gene Silencing of Alzheimer Disease [PDF]
, 2010 A large amount of hidden biological information is contained in the human genome, which is not expressed or revealed in the form of proteins; the usual end product form of gene expression.
Arun Mohan +7 more
core +1 more source
ファージディスプレイ法による自己免疫疾患の自己抗原の探索 [PDF]
, 2018 筑波大学 (University of Tsukuba ...
Niwa Mikio, 丹羽 幹夫
core +2 more sources
A unique mechanism of snRNP core assembly
Nature CommunicationsThe assembly of most spliceosomal snRNP cores involves seven Sm proteins (D1/D2/F/E/G/D3/B) forming a ring around snRNA, typically requiring essential assembly chaperones like the SMN complex, associated with spinal muscular atrophy (SMA). Strikingly, in
Yingzhi Wang +12 more
doaj +1 more source
Alternative splicing events driven by altered levels of GEMIN5 undergo translation
RNA BiologyGEMIN5 is a multifunctional protein involved in various aspects of RNA biology, including biogenesis of snRNPs and translation control. Reduced levels of GEMIN5 confer a differential translation to selective groups of mRNAs, and biallelic variants ...
Rosario Francisco-Velilla +4 more
doaj +1 more source