Results 51 to 60 of about 5,400 (185)
The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly
Cell Reports, 2017 Spinal muscular atrophy (SMA) is a motor neuron disease caused by reduced levels of the survival of motor neuron (SMN) protein. SMN is part of a multiprotein complex that facilitates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs).
Paul G. Donlin-Asp +7 more
doaj +1 more source
The Ribosome Cooperates with the Assembly Chaperone pICln to Initiate Formation of snRNPs
Cell Reports, 2016 The formation of macromolecular complexes within the crowded environment of cells often requires aid from assembly chaperones. PRMT5 and SMN complexes mediate this task for the assembly of the common core of pre-mRNA processing small nuclear ...
Elham Paknia +3 more
doaj +1 more source
Schizophrenia gene networks and pathways and their applications for novel candidate gene selection. [PDF]
PLoS ONE, 2010 Schizophrenia (SZ) is a heritable, complex mental disorder. We have seen limited success in finding causal genes for schizophrenia from numerous conventional studies.
Jingchun Sun +8 more
doaj +1 more source
Functional and structural deficiencies of Gemin5 variants associated with neurological disorders
Life Science Alliance, 2022 Gemin5 clinical variants perturbing the dimerization module and the noncanonical RNA-binding site impair oligomerization, RNA–protein interaction networks, ribosome association, and protein stability.
Rosario Francisco-Velilla +11 more
doaj +1 more source
The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells
, 2009 The cell nucleus contains two closely related structures, Cajal bodies (CBs) and gems. CBs are the first site of accumulation of newly assembled splicing snRNPs (small nuclear ribonucleoproteins) following their import into the nucleus, before they form ...
Nicholas P. Kinnear +9 more
core +1 more source
A comprehensive interaction map of the human survival of motor neuron (SMN) complex [PDF]
, 2007 Assembly of the Sm-class of U-rich small nuclear ribonucleoprotein particles (U snRNPs) is a process facilitated by the macromolecular survival of motor neuron (SMN) complex.
Chari, A. +5 more
core +1 more source
Frontiers in Molecular Biosciences, 2020 The motor neurodegenerative disease spinal muscular atrophy (SMA) is caused by alterations of the survival motor neuron 1 (SMN1) gene involved in RNA metabolism. Although the disease mechanisms are not completely elucidated, SMN protein deficiency leads to abnormal small nuclear ribonucleoproteins (snRNPs) assembly responsible for widespread splicing ...
Sapaly, Delphine +6 more
openaire +4 more sources
GEMINs: Potential Therapeutic Targets for Spinal Muscular Atrophy?
Frontiers in Neuroscience, 2014 The motor neuron degenerative disease spinal muscular atrophy (SMA) remains one of the most frequently inherited causes of infant mortality. Afflicted patients loose the survival motor neuron 1 (SMN1) gene but retain one or more copies of SMN2, a ...
Rebecca eBorg, Ruben J Cauchi
doaj +1 more source
mBio, 2023 Cajal bodies (CBs) are major sub-nuclear structures in most eucaryotic cells. In human adenovirus 5 (Ad5) infection, CBs are reorganized into microfoci in the late phase of infection.
Laura White, Bilgi Erbay, G. Eric Blair
doaj +1 more source
Accurate prediction of peptide binding sites on protein surfaces. [PDF]
PLoS Computational Biology, 2009 Many important protein-protein interactions are mediated by the binding of a short peptide stretch in one protein to a large globular segment in another.
Evangelia Petsalaki +4 more
doaj +1 more source