Results 81 to 90 of about 204,136 (198)

Impact of the 2023 wildfire smoke episodes in Ontario, Canada, on asthma and other health outcomes: an interrupted time-series analysis. [PDF]

open access: yesCMAJ
Chen H   +11 more
europepmc   +1 more source

A Novel Theranostic Strategy for Malignant Pulmonary Nodules by Targeted CECAM6 with 89Zr/131I‐Labeled Tinurilimab

open access: yesAdvanced Science, EarlyView.
This study investigates the integrated diagnostic and therapeutic strategy utilizing 89Zr/131I‐labeled tinurilimab for the management of malignant lung nodules, with a particular focus on lung adenocarcinoma (LUAD). CEACAM6, which is highly expressed in most LUAD patients, activates the Src/FAK signaling pathway, thereby promoting cell proliferation ...
Chongyang Chen   +8 more
wiley   +1 more source

Roflumilast reduces the number of lung adenocarcinomas, inflammation, and emphysema in a smoking-induced mouse model. [PDF]

open access: yesBMC Pulm Med
Sakurai K   +14 more
europepmc   +1 more source

Exercise without Weight Loss Prevents Seasonal Decline in Vitamin D Metabolites: The VitaDEx Randomized Controlled Trial

open access: yesAdvanced Science, EarlyView.
In people with overweight or obesity, regular exercise even without weight loss or vitamin D supplementation completely prevents the usual winter decline in the vitamin D metabolite that maintains health at a cellular level, 1,25(OH)2D3, and ameliorates the decline in the vitamin D status marker 25(OH)D.
Oliver J. Perkin   +11 more
wiley   +1 more source

DNA Molecular Computing with Weighted Signal Amplification for Cancer miRNA Biomarker Diagnostics

open access: yesAdvanced Science, EarlyView.
A molecular computing approach is presented with weighted signal amplification. Polymerase‐mediated strand displacement is employed to assign weights to target miRNAs, reflecting the miRNAs’ diagnostic values, followed by amplification of the weighted signals using localized DNA catalytic hairpin assembly.
Hongyang Zhao   +6 more
wiley   +1 more source

Extracellular Vesicular Delta‐Like Ligand 3 and Subtype Transcription Factors for Small Cell Lung Cancer Diagnosis

open access: yesAdvanced Science, EarlyView.
Small cell lung cancer (SCLC) harbors high molecular heterogeneity. Using a new liquid biopsy assay, SCLC subtypes can be identified by measuring mRNA of subtype transcription factors (ASCL1, POU2F3, and NEUROD1) in exosome‐rich extracellular vesicles. Combining with Delta‐like ligand 3 (DLL3) mRNA in exosomes and its membrane protein in extracellular ...
Hong Li   +27 more
wiley   +1 more source

Chemical Transformations of Infiltrated Wildfire Smoke on Indoor-Relevant Surfaces. [PDF]

open access: yesEnviron Sci Technol
Deeleepojananan C   +5 more
europepmc   +1 more source

Rapid and Noninvasive Early Detection of Lung Cancer by Integration of Machine Learning and Salivary Metabolic Fingerprints Using MS LOC Platform: A Large‐Scale Multicenter Study

open access: yesAdvanced Science, EarlyView.
Salivary metabolic signatures associated with lung cancer are systematically characterized through a self‐developed high‐throughput mass spectrometry Lab‐on‐a‐Chip platform. Utilizing these metabolic fingerprints, SalivaMLD, an integrated machine‐learning‐driven classification model is developed and demonstrates superior performance in detecting lung ...
Shuang Lin   +17 more
wiley   +1 more source

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