Results 31 to 40 of about 1,012,635 (267)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Vaping is associated with increased length of stay among cardiac inpatients

open access: yesTobacco Induced Diseases
Introduction The rapid increase in e-cigarette use, especially among youth, raises significant health concerns. Understanding their impact on high-risk populations, such as those with cardiovascular disease, is crucial for improving patient outcomes and ...
Javad Heshmati   +3 more
doaj   +1 more source

Tobacco tax and the illicit trade in tobacco products in New Zealand

open access: yesAustralian and New Zealand Journal of Public Health, 2015
Objectives: To estimate the size of illegal tobacco trade and consumption and assess the impact of tobacco tax on the illicit tobacco market in New Zealand (NZ). Methods: Data on the import and seizure of legal and illegal tobacco in NZ was obtained from
Ali Ajmal, Veng Ian U
doaj   +1 more source

Passive smoking [PDF]

open access: yesBritish Journal of Cancer, 1982
Before 1980 the argument that passive smoking was a serious health hazard was rather tenuous. It was claimed that it produced allergic reactions, impaired driving ability, reduced exercise tolerance in patients with cardiorespiratory disease and increased the risk of bronchitis and pneumonia in first-year children.
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

To encounter the challenges of tobacco industry: concerted community effort to advocate for policy change

open access: yesTobacco Induced Diseases, 2018
Background and challenges to implementation The Hong Kong Government proposed to enhance pictorial health warnings (PHW), prominently increasing the size to 85%, since May 2015. Opposition and interference of tobacco industry (TI) was fierce.
Antonio Kwong, Vienna Lai
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Tailor-made smoke-free programme to clear the myths of smoking among Hong Kong elder people

open access: yesTobacco Induced Diseases, 2018
Background and challenges to implementation In Hong Kong, over 20% of the 641,300 daily smokers aged 60 years or above. Public's awareness on smoking hazards has increased in recent years.
Antonio Kwong, Vienna Lai
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Smoking prevalence and smoking behavior change among the soldiers in the Korean military

open access: yesTobacco Induced Diseases, 2018
Background Republic of Korea has an obligatory military service. All Korean men in their 20s are obliged to serve the military for 21 months. The purpose of this study was to identify smoking prevalence among the Korean military and to understand how ...
Jinyoung Kim, Sungkyu Lee
doaj   +1 more source

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