This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga+8 more
wiley +1 more source
Exhaled Breath Condensate: Technical and Diagnostic Aspects
Purpose. The aim of this study was to evaluate the 30-year progress of research on exhaled breath condensate in a disease-based approach. Methods. We searched PubMed/Medline, ScienceDirect, and Google Scholar using the following keywords: exhaled breath ...
Efstathia M. Konstantinidi+3 more
doaj +1 more source
Smoking Behaviors and Abstinence in Low-Income Pregnant Women [PDF]
Background: Despite efforts to educate individuals about the hazards of smoking, pregnant women continue to smoke. In the literature, there is less evidence about successful abstinence strategies for low-income women.
Alverson, Elise M, Kessler, Terry A
core +4 more sources
High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson+5 more
wiley +1 more source
Challenges To Quit Smoking Among Smokers In Bandar Baru Salak Tinggi, Sepang, Selangor, Malaysia [PDF]
Cigarette smoking is the largest preventable risk factor for morbidity and mortality in developed countries. The prevalence of smoking is increasing in Malaysia.
A, I. A. (Izzuddin)+5 more
core
Smoking reduction interventions for smoking cessation [PDF]
The standard way most people are advised to stop smoking is by quitting abruptly on a designated quit day. However, many people who smoke have tried to quit many times and may like to try an alternative method. Reducing smoking behaviour before quitting could be an alternative approach to cessation.
Lindson, N+4 more
openaire +5 more sources
Amyotrophic Lateral Sclerosis as a Multistep Process in the United States: A Population‐Based Study
ABSTRACT Background Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease that typically results in death within 3–5 years from symptom onset. However, little is known about the environmental exposures, clinical aspects, or social determinants of health factors that may be associated with the disease.
Jasmine Berry+7 more
wiley +1 more source
Prevalence and attitudes of smoking among secondary school teachers in Hadramout coastal districts, Yemen [PDF]
A descriptive KAP study about smoking was conducted in all the ten secondary schools in Hadramout coastal districts during October 2004 – April 2005 and a total of 317 teachers were enrolled in the study (182 male, 135 female teachers).
Bahaj Ali, Ahmed+1 more
core
Midwives’ engagement in smoking- and alcohol-prevention in prenatal care before and after the introduction of practice guidelines in Switzerland : comparison of survey findings from 2008 and 2018 [PDF]
Background: Evidence suggests that cigarette smoking and alcohol consumption during pregnancy negatively impacts fetal health. Health agencies across countries have developed specific guidelines for health professionals in perinatal care to strengthen ...
Gkiouleka, Anna+5 more
core +3 more sources
ABSTRACT Objective The results of the TRACE‐III trial demonstrated that tenecteplase (TNK) might be comparable to TNK combined with mechanical thrombectomy (MT) for large vessel occlusion (LVO) stroke within 4.5 to 24 h of onset, as tested in the TIMELESS trial.
Chongyang Huang+13 more
wiley +1 more source