Results 71 to 80 of about 6,895,201 (344)

Vascular cell‐specific roles of mineralocorticoid receptors in pulmonary hypertension

Pulmonary Circulation, 2021
Abnormalities that characterize pulmonary arterial hypertension include impairment in the structure and function of pulmonary vascular endothelial and smooth muscle cells.
Divya P. Menon, Guanming Qi, Seung K. Kim, M. Elizabeth Moss, Krishna C. Penumatsa, Rod R. Warburton, Deniz Toksoz, Jamie Wilson, Nicholas S. Hill, Iris Z. Jaffe, Ioana R. Preston   +10 more
doaj   +1 more source

Smooth Muscle Enriched Long Noncoding RNA (SMILR) Regulates Cell Proliferation

Circulation, 2016
Background— Phenotypic switching of vascular smooth muscle cells from a contractile to a synthetic state is implicated in diverse vascular pathologies, including atherogenesis, plaque stabilization, and neointimal hyperplasia.
M. Ballantyne, Karine Pinel, R. Dakin, A. Vesey, L. Diver, Ruth M. Mackenzie, R. García, P. Welsh, N. Sattar, G. Hamilton, N. Joshi, M. Dweck, J. Miano, M. McBride, D. Newby, R. Mcdonald, A. Baker   +16 more
semanticscholar   +1 more source

Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. [PDF]

, 2012
The transcription factors Elk1 and serum response factor (SRF) are central regulators of cell cycle and phenotype in various cell types. Elk1 is activated by phosphorylation (serine-383), while activation of SRF requires its co-factor, myocardin ...
Christian G Stief, Strittmatter, Frank, Martin Hennenberg, Waidelich, Raphaela, Beckmann, Christer, Füllhase, Claudius, Rutz, Beata, Montorsi, Francesco, Petter Hedlund, Christer Beckmann, Christian Gratzke, Stief, Christian Georg, Raphaela Waidelich, Hedlund, Petter, Frank Strittmatter, Karl-Erik Andersson, Andersson, Karl-Erik, Francesco Montorsi, Hennenberg, Martin, Gratzke, Christian, Beata Rutz, Claudius Füllhase   +21 more
core   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice.

PLoS Pathogens, 2007
Interleukin 4 receptor alpha (IL-4Ralpha) is essential for effective clearance of gastrointestinal nematode infections. Smooth muscle cells are considered to play a role in the type 2 immune response-driven expulsion of gastrointestinal nematodes ...
William G C Horsnell, Antony J Cutler, J Claire Hoving, Helen Mearns, Elmarie Myburgh, Berenice Arendse, Fred D Finkelman, Gary K Owens, Dave Erle, Frank Brombacher   +9 more
doaj   +1 more source

Integrin-linked kinase functions as a downstream signal of platelet-derived growth factor to regulate actin polymerization and vascular smooth muscle cell migration

BMC Cell Biology, 2010
Background Vascular smooth muscle cell migration and accumulation in response to growth factors extensively contribute to the development of intimal thickening within the vessel wall.
van Breemen Cornelis, Dedhar Shoukat, Gray Virginia, Yazdi Sahar, Esfandiarei Mitra   +4 more
doaj   +1 more source

Silencing of NOTCH3 Signaling in Meniscus Smooth Muscle Cells Inhibits Fibrosis and Exacerbates Degeneration in a HEYL‐Dependent Manner

Advanced Science, 2023
The mechanisms of meniscus fibrosis and novel ways to enhance fibrosis is unclear. This work reveals human meniscus fibrosis initiated at E24 weeks. Smooth muscle cell cluster is identified in embryonic meniscus, and the combined analysis with previous ...
Hao Sun, Fangzhou Liu, Zhencan Lin, Zongrui Jiang, Xingzhao Wen, Jie Xu, Zhiqi Zhang, Ruofan Ma   +7 more
doaj   +1 more source

Endothelin-Induced Sarcoplasmic Reticulum Calcium Depletion Waves in Vascular Smooth Muscle Cells [PDF]

, 2011
Agonist-stimulated waves of elevated cytoplasmic Ca2+ concentration ([Ca2+]i ) regulate blood vessel tone and vasomotion in vascular smooth muscle. Previous studies employing cytoplasmic Ca2+ indicators revealed that these Ca2+ waves were generated by a ...
Cornelis van Breemen, Jeremy Hoskins, Arash Y. Tehrani, Mitra Esfandiarei, Yohan Choi, Nicola Fameli, Jeremy G. Hoskins, Arash Tehrani   +7 more
core   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Herbal extracts modulate the amplitude and frequency of slow waves in circular smooth muscle of mouse small intestine [PDF]

, 2004
Background: Herbal preparations like STW 5 (Iberogast(R)) are widely used drugs in the treatment of dyspepsia and motility-related disorders of the gastrointestinal tract.
Weiser, D., Storr, Martin, Göke, B., Schirra, J., Kelber, O., Sibaev, A., Allescher, H. D.   +6 more
core   +1 more source