Results 51 to 60 of about 888,620 (289)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Calibration-free gaze interfaces based on linear smooth pursuit

Journal of Eye Movement Research, 2020
Since smooth pursuit eye movements can be used without calibration in spontaneous gaze interaction, the intuitiveness of the gaze interface design has been a topic of great interest in the human-computer interaction field.
Zhe Zeng, Felix Wilhelm Siebert, Antje Christine Venjakob, Matthias Roetting   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Examination of the relationship between the Groffman Visual Tracing test and Smooth Pursuit test: a cross-sectional analysis

The Egyptian Journal of Otolaryngology
Purpose Smooth Pursuit and Groffman Visual Tracing (GVT) tests are tracking tests used to evaluate oculomotor processes. This study aims to investigate the relationship between GVT and the Smooth Pursuit test, which assesses various aspects of oculomotor
Aysenur Aykul Yagcıoglu, Muhammed Pınar, Burak Ozturk   +2 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Properties of smooth pursuit and visual motion reaction time to second-order motion stimuli.

PLoS ONE, 2020
A large number of psychophysical and neurophysiological studies have demonstrated that smooth pursuit eye movements are tightly related to visual motion perception.
Takeshi Miyamoto, Kenichiro Miura, Tomohiro Kizuka, Seiji Ono   +3 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Functional connectivity during smooth pursuit eye movements

, 2020
Contains supplementary material, behavioural data and analysis script for "Functional connectivity during smooth pursuit eye movements ...
Maria Steffens, Ulrich Ettinger, Anna-Maria Kasparbauer, Inga Meyhöfer, Peter Trautner, Rebekka Schröder   +5 more
core   +2 more sources

Using smooth pursuit calibration for difficult-to-calibrate participants

Journal of Eye Movement Research, 2017
Although the 45-dots calibration routine of a previous study (Blignaut, 2016) provided very good accuracy, it requires intense mental effort and the routine proved to be unsuccessful for young children who struggle to maintain concentration.
Pieter Blignaut
doaj   +1 more source

Supersaliency: A Novel Pipeline for Predicting Smooth Pursuit-Based Attention Improves Generalisability of Video Saliency

IEEE Access, 2020
Predicting attention is a popular topic at the intersection of human and computer vision. However, even though most of the available video saliency data sets and models claim to target human observers' fixations, they fail to differentiate them from ...
Mikhail Startsev, Michael Dorr
doaj   +1 more source