Results 71 to 80 of about 229,880 (284)

A Model of the Smooth Pursuit Eye Movement with Prediction and Learning

open access: yesApplied Bionics and Biomechanics, 2010
Smooth pursuit is one of the five main eye movements in humans, consisting of tracking a steadily moving visual target. Smooth pursuit is a good example of a sensory-motor task that is deeply based on prediction: tracking a visual target is not possible ...
Davide Zambrano   +3 more
doaj   +1 more source

Ocular Motor Function in Patients with Bilateral Vestibular Weakness [PDF]

open access: yesIranian Journal of Otorhinolaryngology, 2016
Introduction: Patients with bilateral weakness (BW) have many difficulties in gaze stability that interfere with their normal function. The aim of this study was to evaluate ocular motor functions in patients with BW to better understand the problem of ...
Seyyed Amir Hossein Ghazizadeh Hashemi   +3 more
doaj   +1 more source

Normal Pursuit-System Limitations— First Discovered in Infantile Nystagmus Syndrome [PDF]

open access: yes, 2013
Infantile nystagmus syndrome (INS) patients occasionally have impaired pursuit. Model and patient data identified relative timing between target motion initiation and INS-waveform saccades as the cause. We used a new stimulus, the “step-pause-ramp” (SPR),
Dell’Osso, Louis F.   +1 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Robust generalization of tuning to self-induced sensation

open access: yesiScience
Summary: Perceptual and sensorimotor learning is often specific to the trained stimuli and movement parameters. This specificity also applies to recalibrating sensory and motor maps, such as saccadic eye movements in response to systematic visual errors.
Rozana Ovsepian   +2 more
doaj   +1 more source

Predicting Trial-by-Trial Variation in Oculomotor Behavior Using Multivariate Electroencephalography Theta Phase

open access: yesIEEE Access, 2020
When we interact with our environment, there is often a significant amount of variations in our behavioral responses to incoming sensory input even when inputs are identical.
Woojae Jeong   +3 more
doaj   +1 more source

Hidden Pursuits: Evaluating Gaze-selection via Pursuits when the Stimuli's Trajectory is Partially Hidden [PDF]

open access: yes, 2018
The idea behind gaze interaction using Pursuits is to leverage the human's smooth pursuit eye movements performed when following moving targets. However, humans can also anticipate where a moving target would reappear if it temporarily hides from their ...
Alt, Florian   +4 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Multimodal personalization of transcranial direct current stimulation for modulation of sensorimotor integration

open access: yesNeuroImage
Transcranial direct current stimulation (tDCS) for the modulation of smooth pursuit eye movements provides an ideal model for investigating sensorimotor integration.
Jan-Ole Radecke   +12 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

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