Results 31 to 40 of about 249,477 (266)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Approximating Continuous Function by Smooth Functions on Orbit Spaces

Mathematics
In this paper, we study the approximation of continuous functions on a subclass of singular space—the subcartesian space. As is well known, the orbit space of the proper action of a Lie group on a smooth manifold is a subcartesian space.
Luyang Zhou, Qianqian Xia
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Crossing the Boundary: The Space of Hardy‘s Wessex Novels

American and British Studies Annual, 2013
The article focuses on concepts of space in Thomas Hardy‘s Wessex novels, The Return of the Native, Tess of the d’Urbervilles and The Woodlanders. The theoretical approach used here is centred on two general categories of defining space.
Alice Sukdolová
doaj  

Properties of Chmielinski-orthogonality using Kadets-Klee property

Iraqi Journal for Computer Science and Mathematics, 2022
The aim of this paper is to study new results of an approximate orthogonality of Birkhoff-James techniques in real Banach space , namely Chiemelinski orthogonality (even there is no ambiguity between the concepts symbolized by orthogonality) and provide
saied Johnny, Buthainah A. A. Ahmed
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Study of Birkhoff Orthogonal Sets in Smooth Banach Spaces

Journal of Harbin University of Science and Technology
Referring to the definition of orthogonal set in inner product space，the concept of Birkhoff orthogonal set is introduced in finite-dimensional real Banach spaces，and the problem of whether there exists a Birkhoff orthogonal set whose number of ...
WANG Xiaomei, JI Donghai
doaj   +1 more source

Observability and Controllability Analysis for Sandwich Systems with Backlash

International Journal of Applied Mathematics and Computer Science, 2015
In this paper, an approach to analyze the observability and controllability of sandwich systems with backlash is proposed. In this method, a non-smooth state-space function is used to describe the sandwich systems with backlash which are also non-smooth ...
Luo Na, Tan Yonghong, Dong Ruili
doaj   +1 more source

Metric topology on the moduli space

Applied General Topology, 2021
We define the smooth Lipschitz topology on the moduli space and show that each conformal class is dense in the moduli space endowed with Gromov-Hausdorff topology, which offers an answer to Tuschmann’s question.
Jialong Deng
doaj   +1 more source