Results 41 to 50 of about 249,477 (266)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Approximation of Bivariate Functions via Smooth Extensions

open access: yesThe Scientific World Journal, 2014
For a smooth bivariate function defined on a general domain with arbitrary shape, it is difficult to do Fourier approximation or wavelet approximation. In order to solve these problems, in this paper, we give an extension of the bivariate function on a ...
Zhihua Zhang
doaj   +1 more source

Rotundity and smoothness in conjugate spaces [PDF]

open access: yesProceedings of the American Mathematical Society, 1976
It is shown that the James space J J admits an equivalent norm such that its third conjugate space is rotund.
openaire   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Parametric general variational-like inequality problem in uniformly smooth Banach space

open access: yesFixed Point Theory and Applications, 2006
Using the concept of - -proximal mapping, we study the existence and sensitivity analysis of solution of a parametric general variational-like inequality problem in uniformly smooth Banach space.
Kazmi KR, Khan FA
doaj   +2 more sources

ON TWO-SIDED UNIDIRECTIONAL MEAN VALUE INEQUALITY IN A FRÉCHET SMOOTH SPACE

open access: yesUral Mathematical Journal, 2023
The paper is devoted to a new unidirectional mean value inequality for the Fréchet subdifferential of a continuous function. This mean value inequality finds an intermediate point and localizes its value both from above and from below; for this reason ...
Dmitry V. Khlopin
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Orthogonality in smooth countably normed spaces

open access: yesJournal of Inequalities and Applications, 2021
We generalize the concepts of normalized duality mapping, J-orthogonality and Birkhoff orthogonality from normed spaces to smooth countably normed spaces.
Sarah Tawfeek   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Ordinary Smooth Topological Spaces

open access: yesInternational Journal of Fuzzy Logic and Intelligent Systems, 2012
In this paper, we introduce the concept of ordinary smooth topology on a set X by considering the gradation of openness of ordinary subsets of X. And we obtain the result [Corollary 2.13] : An ordinary smooth topology is fully determined its decomposition in classical topologies. Also we introduce the notion of ordinary smooth [resp.
Pyung-Ki Lim, Byeong-Guk Ryoo, Kul Hur
openaire   +2 more sources

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