Results 151 to 160 of about 29,268 (294)
Smoothened regulation in the Hedgehog signaling pathway [PDF]
, 2013 Hedgehog signaling is a pathway essential in embryonic development, adult stem cell maintenance, and is implicated in the formation and progression of cancer. Signaling in this pathway is triggered when the secreted protein Hedgehog binds to its membrane
Nedelcu, Daniel
core
, 2006 Sharp borders between cells with different developmental fates are important for patterning of invertebrates, but are not well understood in vertebrates.
Pearson, B. +9 more
core +1 more source
Arthritis Care &Research, Accepted Article.Objective JAK inhibitors (JAKis) have shown promising effects in early‐phase studies of SSc. We aimed to assess the safety and explore effectiveness of JAKis compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the EUSTAR cohort was performed.
Stefano Di Donato +27 more
wiley +1 more source
Discovery of NVP-LDE225, a potent and selective biphenyl-3-carboxamide smoothened antagonist.
, 2010 Blockade of aberrant hedgehog (Hh) signaling has shown promise for therapeutic intervention in cancer. A cell-based phenotypic high throughput screen was performed, and lead structure (1) was identified as an inhibitor of the Hh pathway via antagonism ...
Jiang, Jiqing +25 more
core +1 more source
A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems
International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam +2 more
wiley +1 more source
Targeting of Smoothened for therapeutic gain.
, 2014 International audienceThe Smoothened (Smo) receptor is a key transducer of the Hedgehog (Hh) signaling pathway, which plays a critical role in tissue maintenance and repair.
Rognan, Didier +3 more
core +1 more source
Advanced Engineering Materials, EarlyView.Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt +8 more
wiley +1 more source
Advanced Engineering Materials, EarlyView.The tribological behavior of 100Cr6 steel spheres textured via Vickers microindentation is evaluated under lubricated sliding by varying both dimple size and density. Fine and dense textures significantly reduce friction across all lubrication regimes, while large dimples increase it.
Farideh Davoodi +3 more
wiley +1 more source
, 2009 Abnormal activation of the Hh pathway has been linked to sevral types of human cancers, and the development of small-molecule inhibitors of this pathway represents a promising route towards novel anti-cancer therapeutics.
Dai, Miao +20 more
core +1 more source
Laser Powder Bed Fusion of Alumina: Effects of Scanning Strategies on External and Internal Defects
Advanced Engineering Materials, EarlyView.This study investigates how scanning strategies affect pure alumina in laser powder bed fusion. Linear 45° scanning yields uniform surfaces but high porosity, while the island‐concentric strategy provides higher density with through‐holes favorable for infiltration. Findings highlight pathways toward optimizing defect‐free alumina parts.
Mohamed Abdelmoula +7 more
wiley +1 more source