Results 41 to 50 of about 889,338 (324)
Smoothing migration intensities with P-TOPALS
Demographic Research, 2020 Background: Age-specific migration intensities often display irregularities that need to be removed by graduation, but two current methods for doing so, parametric model migration schedules and non-parametric kernel regression, have their limitations ...
Sigurd Dyrting
doaj +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
A Probabilistic Perspective on Gaussian Filtering and Smoothing
, 2010 We present a general probabilistic perspective on Gaussian filtering and smoothing. This allows us to show that common approaches to Gaussian filtering/smoothing can be distinguished solely by their methods of computing/approximating the means and ...
Deisenroth, MP, Ohlsson, H
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Quantum state smoothing: Why the types of observed and unobserved measurements matter
, 2019 We investigate the estimation technique called quantum state smoothing introduced by Guevara and Wiseman [Phys.~Rev.~Lett.~{\bf 115}, 180407 (2015)], which offers a valid quantum state estimate for a partially monitored system, conditioned on the ...
Chantasri, Areeya +2 more
core +1 more source
Biased Estimates of Omega from Comparing Smoothed Predicted Velocity Fields to Unsmoothed Peculiar Velocity Measurements [PDF]
, 2000 We show that a regression of unsmoothed peculiar velocity measurements against peculiar velocities predicted from a smoothed galaxy density field leads to a biased estimate of the cosmological density parameter Omega, even when galaxies trace the ...
. +3 more
core +2 more sources
State-Space Models on the Stiefel Manifold with a New Approach to Nonlinear Filtering
Econometrics, 2018 We develop novel multivariate state-space models wherein the latent states evolve on the Stiefel manifold and follow a conditional matrix Langevin distribution.
Yukai Yang, Luc Bauwens
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Some remarks on Abelian dominance [PDF]
, 1997 We use a renormalisation group based smoothing to address two questions related to Abelian dominance. Smoothing enables us to extract the Abelian heavy-quark potential from time-like Wilson loops on Polyakov gauge projected configurations.
Bali +8 more
core +3 more sources