Results 51 to 60 of about 1,663,953 (297)

A hybrid simple exponential smoothing-barnacles mating optimization approach for parameter estimation: Enhancing COVID-19 forecasting in Malaysia

open access: yesMethodsX
Single or simple exponential smoothing (SES) is a time series forecasting model popular among researchers due to its simplicity and ease of use. SES only requires one smoothing parameter, alpha, to control how quickly the influence of past observations ...
Azlan Abdul Aziz   +4 more
doaj   +1 more source

Sequential Monte Carlo Smoothing with Parameter Estimation [PDF]

open access: yesBayesian Analysis, 2018
23 pages, 7 figures, 4 ...
Yang, Biao   +2 more
openaire   +3 more sources

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

open access: yesFEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph   +7 more
wiley   +1 more source

COMPUTER-ASSISTED CHOICE OF SMOOTHING PARAMETER IN KERNEL METHODS APPLIED IN ECONOMIC ANALYSES

open access: yesQuantitative Methods in Economics, 2014
In the kernel method, it is necessary to determine the value of the smoothing parameter. Not without significance is the fact of using the objectivity in the selection of this parameter and a certain automation of the selection procedure, which is ...
Aleksandra Baszczyńska
doaj  

Cross-Validation, Information Theory, or Maximum Likelihood? A Comparison of Tuning Methods for Penalized Splines

open access: yesStats, 2021
Functional data analysis techniques, such as penalized splines, have become common tools used in a variety of applied research settings. Penalized spline estimators are frequently used in applied research to estimate unknown functions from noisy data ...
Lauren N. Berry, Nathaniel E. Helwig
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

open access: yesFEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain   +11 more
wiley   +1 more source

Approximate Interpolation with Applications to Selecting Smoothing Parameters

open access: yesNumerische Mathematik, 2005
An approximation problem can be shortly stated as follows: for a finite set \(X\) of points situated in a bounded set \(\Omega\) and a corresponding data values of an unknown function \(f \in C(\Omega)\), a function \(s_{f,X} \in C(\Omega)\) to produce a good approximation is required.
Holger Wendland, Christian Rieger
openaire   +4 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

PERBANDINGAN PERAMALAN METODE DOUBLE EXPONENTIAL SMOOTHING SATU PARAMETER BROWN DAN METODE DOUBLE EXPONENTIAL SMOOTHING DUA PARAMETER HOLT [PDF]

open access: yes, 2016
Peramalan merupakan suatu proses atau metode dalam meramal suatu peristiwa yang akan terjadi pada masa yang akan datang. Pemulusan eksponensial adalah suatu metode peramalan rata-rata bergerak yang melakukan pembobotan menurun secara eksponensial ...
Bidangan, Julnita   +2 more
core   +1 more source

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