Results 121 to 130 of about 102,732 (218)

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source

New Magnetite Reference Material for SIMS δ18O Measurements and a Study of Precision and Accuracy Due to Crystal Orientation Effects

Geostandards and Geoanalytical Research, EarlyView.
Key Points A new magnetite reference material (PF21mt) is available for δ18O measurements by SIMS. Reproducibility of measurement results in two laboratories suggest orientation bias of ±2‰ (2s) at 20 keV. Repeatability improves to ±1‰ (2s) when using a 13 keV protocol, suggesting reduced orientation bias. In situ isotope ratio measurements provide the
Michelle Ulrich, Daniela Rubatto, Maria Rosa Scicchitano, Benita Putlitz, Thomas Bovay   +4 more
wiley   +1 more source

Prediction of organic acid concentration in BRS Capiaçu elephant grass silage

Grassland Science, EarlyView.
Abstract This study aimed to develop prediction models for organic acid concentrations in Capiaçu grass (Pennisetum purpureum Schum) silage, based on fermentation parameters and chemical composition. Data were obtained from an experiment that evaluated BRS (Brazil Seeds) Capiaçu grass silage with the inclusion of dehydrated cashew pseudofruit ...
Isadora Osório Maciel Aguiar Freitas, Antonio Leandro Chaves Gurgel, Vitor Cardoso Queiroz, Marcos Jácome de Araújo, Tairon Pannunzio Dias‐Silva, Rafael de Souza Miranda, Laryssa Geovana Rocha do Amarante, Sheila Vilarindo de Sousa, Luís Carlos Vinhas Ítavo, Gelson dos Santos Difante, João Virgínio Emerenciano Neto   +10 more
wiley   +1 more source

Recovery From Anorexia Nervosa: A Concept Analysis

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim Despite decades of research, we still know surprisingly little about how best to bring about lasting recovery from anorexia nervosa (AN). Furthermore, there is a lack of consensus in the research and treatment communities about what constitutes recovery from AN, or whether “recovery” is even an appropriate term to use in this context.
Sarah Ramsay, Kendra Allison
wiley   +1 more source

International Dermoscopy Society consensus recommendations for the management of lentigo maligna

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Lentigo maligna (LM) poses diagnostic and therapeutic challenges amid rising incidence and limited high‐quality evidence. This international expert consensus provides pragmatic, evidence‐based and expertise‐informed guidance on LM diagnosis and management.
Ana‐Maria Forsea, Riccardo Pampena, Bengu Nisa Akay, Zoe Apalla, Giuseppe Argenziano, Giulia Briatico, Ralph Braun, Horacio Cabo, Raul Cabrera, Cristina Carrera, Elisa Cinotti, Claudio Conforti, Enzo Errichetti, Gerardo Ferrara, Roberta Giuffrida, Stefania Guida, Pascale Guitera, Allan C. Halpern, Stephen Heyes, Rainer Hofmann‐Wellenhof, Angela M. Hong, Natalia Jaimes, Raimonds Karls, Harald Kittler, Teresa Kränke, Konstantinos Liopyris, Jie Liu, Caterina Longo, Josep Malvehy, Ashfaq A. Marghoob, Hoda Moneib, David Moreno Ramirez, Elvira Moscarella, Eduardo Nagore, Cristian Navarrete‐Dechent, John Paoli, Giovanni Pellacani, Ketty Peris, Susana Puig, Cliff Rosendahl, Lidia Rudnicka, Ahmed Sadek, Philippe Saiag, Gabriel Salerni, Alon Scope, Hans Peter Soyer, Michela V. Starace, Wilhelm Stolz, David L. Swanson, Luc Thomas, Philipp Tschandl, Iris Zalaudek, Aimilios Lallas   +52 more
wiley   +1 more source

Aerobic scope is sustained through a heatwave in juvenile Atlantic salmon (Salmo salar)

Journal of Fish Biology, EarlyView.
Abstract Aquatic ectotherms are vulnerable to heatwave‐induced physiological stress, which arises from increased energy demands and reduced dissolved oxygen content in warmer waters. Understanding thermal physiology is critical for predicting how commercially and ecologically important populations could be affected by the increasing risk of rising ...
Lucy Cotgrove, Sergey Morozov, Miika Raitakivi, Evan Sala, Jenni M. Prokkola   +4 more
wiley   +1 more source

The emergence of pathogens on fish in an impacted estuary and the role of non‐native piranhas in a potential bacterial infectious outbreak

Journal of Fish Biology, EarlyView.
Abstract As many tropical aquatic ecosystems worldwide, the Doce River estuary (DRE, southeastern Brazil) has increasingly faced multiple anthropogenic threats, including deforestation, mining, species introduction and water management. The 2015 collapse of the Fundão iron ore tailings dam severely changed water properties and increased heavy metal ...
Ryan Andrades, Helder C. Guabiroba, Kathiani V. Bastos, Vítor L. A. Rodrigues, Marcelo R. D. Santos, Clarisse M. Arpini, Mayra Cunha Flecher, Helen A. Pichler, Ciro C. Vilar, Maurício Hostim‐Silva, Jean‐Christophe Joyeux   +10 more
wiley   +1 more source

The impact of isosmotic conditions on the metabolism and hypoxia tolerance of a reportedly oxyconforming teleost

Journal of Fish Biology, EarlyView.
Abstract Fish must manage the competing demands of ion balance and gas exchange across the gills – a physiological tension known as the osmorespiratory compromise. In dynamic estuarine environments, the osmorespiratory compromise may be exacerbated by variable salinity and periods of hypoxia that demand high respiratory work.
Timothy D. Clark, Luis L. Kuchenmüller, Elizabeth C. Hoots, Maryane Gradito, Jake M. Martin   +4 more
wiley   +1 more source

Atrial Secondary Mitral Regurgitation: Pathophysiology, Diagnosis, and Surgical Implications. [PDF]

Medicina (Kaunas)
Venturiello D, Campolongo G, Navarra EM, Speziale G.   +3 more
europepmc   +1 more source