Results 171 to 180 of about 102,732 (218)

Cause-specific mortality beyond prostate cancer in young men: a population-based study of second malignancies and non-tumor causes. [PDF]

Am J Transl Res
Kang Y, Liu J, Lin Y, Pang L.
europepmc   +1 more source

Molecular analysis of 3D domain swapping in the acylphosphatase from Escherichia coli

Acta Crystallographica Section D, Volume 82, Issue 4, Page 336-347, April 2026.
Structures of the monomer and intertwined dimer of the acylphosphatase from E. coli shed light on the molecular basis of its 3D domain swapping.Three‐dimensional domain swapping is a mechanism by which proteins form oligomers. At present, the molecular basis that dictates whether some proteins fold in their monomeric form or as intertwined oligomers is
Sergio Martínez-Rodríguez, Jose A. Gavira, M. Carmen Salinas-Garcia, Montserrat Andujar-Sánchez, Ana Camara-Artigas   +4 more
wiley   +1 more source

Dynamic Lysine Acetylation Disrupts Isocitrate Lyase Function and Enables Metabolic Optimisation

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Acetyl‐phosphate–dependent acetylation of E. coli isocitrate lyase (ICL) at K13 and K308 inhibits its activity, while CobB‐mediated deacetylation restores function. Introducing K13R/K308R mutations enhances metabolic balance and increases lycopene yield by 61%, providing a promising approach to optimise microbial cell factories through natural ...
Adrián Martínez‐Vivancos, Beatriz Gomariz‐Turpin, Gema Lozano‐Terol, Rosa Alba Sola‐Martínez, Álvaro Ortega, Julia Gallego‐Jara, Teresa de Diego Puente   +6 more
wiley   +1 more source

Gender-stratified analysis of sepsis mortality in cancer: a 45-year population-based cohort study. [PDF]

JNCI Cancer Spectr
Guo Y, Lin Z, Zhang W, Chen H, Liu Y, Liu J, Zhang J, Zhang A, Mao S, Yao X.   +9 more
europepmc   +1 more source

In vitro culture, cryopreservation, and field reintroduction of the endangered Mingan thistle

Conservation Biology, Volume 40, Issue 2, April 2026.
Abstract Current plant conservation efforts are hindered by, for example, poor seed germination, low viability, and insufficient propagation and preservation technologies. To address these problems, we devised an approach to plant conservation that integrates conservation, preservation, and restoration (CPR), which uses advanced in vitro techniques. We
Mukund R. Shukla, Wenlu Bi, Marie‐Claude Roy, Dénommée Nancy, Praveen K. Saxena   +4 more
wiley   +1 more source

Integrative multi-omics analysis of macrophage polarization-related genes in atherosclerosis development. [PDF]

Clin Epigenetics
Gao J, Huang P, Zhang Y.
europepmc   +1 more source

Prevalence, incidence, mortality and causes of death in a large cohort of patients with rheumatoid arthritis: an Italian population-based study. [PDF]

RMD Open
Osele AG, Zen M, Salmaso L, Amidei CB, Fedeli U, Giollo A, Ragno D, Vesentini F, Salvato M, Ramonda R, Saia M, Doria A.   +11 more
europepmc   +1 more source

Mitochondria‐Related Pathogenic Genes in Paediatric Asthma: A Multi‐Omics Mendelian Randomization Study

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Mitochondrial dysfunction is implicated in asthma pathogenesis, but causal roles of mitochondrial‐related genes in paediatric asthma remain unclear. We performed a multi‐omics Mendelian randomization study integrating GWAS data from paediatric asthma cohorts with blood‐based methylation quantitative trait loci (mQTLs), expression QTLs (eQTLs ...
Biyu Zhang, Yaqin Li, Bo Ding, Xiaoyan Li, Yanming Lu   +4 more
wiley   +1 more source

Trends in mortality due to GPA/MPA across Europe: insights from a decade of death registrations. [PDF]

Rheumatology (Oxford)
Biddle K, Taylor A, Trimble TJ, Grainge MJ, Lanyon P, Galloway J, Pearce FA.   +6 more
europepmc   +1 more source

Calebin A mitigates oxidative stress and inflammation in diabetic nephropathy via Nrf2/HO‐1 and NF‐κB signaling pathways

Journal of Diabetes Investigation, Volume 17, Issue 4, Page 588-598, April 2026.
Representative histological images of kidney tissues stained with hematoxylin and eosin (H&E) at 400× magnification (n = 6). ABSTRACT Background Diabetic nephropathy (DN) is a common and serious microvascular complication of diabetes mellitus, primarily driven by persistent hyperglycemia‐induced oxidative stress and chronic inflammation.
Reyhane Ghayour Vatanparast, Mahdieh Aliyari, Mahla Palizkaran Yazdi, Soodeh Alidadi, Mohammad Reza Sokhanvar, Sercan Karav, Prashant Kesharwani, Hossein Hosseini, Amirhossein Sahebkar   +8 more
wiley   +1 more source