Results 201 to 210 of about 49,260 (315)

A two-gene prognostic model for lung adenocarcinoma using summary-data-based Mendelian randomization analysis and Cox proportional hazards regression. [PDF]

Future Sci OA
Xu J, Liu X, Lu Z, Wu X, Yu X, Wang S.
europepmc   +1 more source

Pharmacological Targets for Periodontitis: A Systematic Review of Drug‐Target Mendelian Randomisation Studies

Journal of Periodontal Research, EarlyView.
This systematic review evaluated drug‐target Mendelian randomisation studies on periodontitis. Twelve studies identified host‐response‐related targets mainly involved in inflammatory, complement, and immune pathways. Although some targets were linked to existing drugs, the evidence remains preliminary and heterogeneous, requiring replication and ...
Luigi Nibali, Jing Kang, Simon Haworth, Alessandro Polizzi, Gaetano Isola   +4 more
wiley   +1 more source

Genetically predicted ZDHHC8 expression and osteoporosis risk: A two-sample Mendelian randomization and metabolite mediation study. [PDF]

Medicine (Baltimore)
Yang W, Yang K, Xu S, Yang S.
europepmc   +1 more source

Fragmented Opposition? The Radical Left, Ukraine and European Defence in the 10th European Parliament

JCMS: Journal of Common Market Studies, EarlyView.
Lien Jansen, Wolfgang Wagner
wiley   +1 more source

Drought and salinity stress remodel Asian rice (Oryza sativa) leaf development through cell‐type‐specific regulatory programs

New Phytologist, EarlyView.
Osmotic stressors induce developmental and physiological changes in rice (Oryza sativa) seedlings, which are modulated by cell‐type‐specific gene expression and regulatory networks. We exposed plants to two levels of drought and salinity stress and measured the effects of these stressors on developing leaves by measuring physiological traits, ion ...
Sean M. Robertson, Obaid Maqsood, Chi Dang, Asher Pasha, Claudio Stasolla, Nicholas J. Provart, Olivia Wilkins   +6 more
wiley   +1 more source

Integrative Proteogenomics and Single-Cell Transcriptomics Prioritize Candidate Causal Proteins and Therapeutic Targets in Age-Related Macular Degeneration. [PDF]

Int J Mol Sci
Wen L, Li F, Liu Y, Zhang K, Mao A, Liu L, Lv X, Geng L, Yu F, Feng L, Kan H.   +10 more
europepmc   +1 more source

A Century of Understanding and Harnessing Heterosis

Plant Breeding, EarlyView.
ABSTRACT Heterosis has shaped modern plant breeding since Darwin's 19th century observations that outcrossing restores vigour lost through selfing. While 100 years old, its mechanistic basis and deployability remain actively debated. Classical models of dominance, overdominance and epistasis provided the foundation for hybrid breeding and converted ...
Mohsen Mohammadi
wiley   +1 more source

Multi-omics Mendelian randomization analysis identifies SPATA20 as a cross-omic target in primary open angle glaucoma. [PDF]

Int J Ophthalmol
Ouyang ZK, Ge L, Yu ST, Luo JY.
europepmc   +1 more source

Geometrical isomerization of hydroxycinnamic acid under UV‐light: Structural plasticity as a driver of metabolite complexity

Photochemistry and Photobiology, EarlyView.
UV irradiation drives metabolite complexity through photoisomerization of hydroxycinnamic acid‐containing compounds in plants. The olefin functional group of hydroxycinnamic acid enables structural plasticity through trans/cis isomerization. Multiple chromophores within a molecule can amplify UV‐induced transformations.
Mailane Rose Sekgobela, Lutendo Michael Mathomu, Nakisani Babra Moyo, Rudzani Nemadzhilili, Mwadham Mwombeki Kabanda, Ntakadzeni Edwin Madala   +5 more
wiley   +1 more source

Challenging the limits of mitral-TEER: a PASCAL case in the anatomical 'red zone': a case report. [PDF]

Eur Heart J Case Rep
Papadopoulos K, Khan LS, Tzikas A, Badescu AC, Vannan MA.   +4 more
europepmc   +1 more source