Results 41 to 50 of about 49,260 (315)
Angewandte Chemie, EarlyView.Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey +13 more
wiley +2 more sources
Reversal of Chorea Hyperglycemia Basal Ganglia Syndrome With Glycemic Control: A Case Report
Clinical Medicine Insights: Case ReportsChorea Hyperglycemia Basal Ganglia Syndrome (CHBG) is an uncommon neurological complication arising in diabetic patients with severe, non-ketotic hyperglycemia.
Sumanth Gundraju +6 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai +13 more
wiley +1 more source
Neutronic and thermal-hydraulic performance analysis of a novel thorium-based fuel in dual-cooled annular assemblies for SMR applications [PDF]
EPJ Web of ConferencesA coupled neutronic and thermal-hydraulic assessment is performed for a dual-cooled annular fuel concept applied to light-water SMR conditions. A mixed thorium-based oxide, (Th-233U-235U)O2, is evaluated against conventional UO2 and solid-pin benchmarks ...
Rifai Hanan +7 more
doaj +1 more source
, 2022 Supplemental material, sj-docx-1-smr-10.1177_00491241221122616 for The Extended Computational Case Method: A Framework for Research Design by Juan Pablo Pardo-Guerra and Prithviraj Pahwa in Sociological Methods ...
Juan Pablo Pardo-Guerra (13769270) +1 more
core +1 more source
Arthritis Care &Research, EarlyView.Biomedical research involving US veterans continues to advance health care beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both veteran ...
Austin M. Wheeler +20 more
wiley +1 more source
, 2023 Supplemental material, sj-docx-1-smr-10.1177_00491241231156968 for Video Data Analysis and Police Body-Worn Camera Footage by John D. McCluskey and Craig D.
John D. McCluskey (14650689) +1 more
core +1 more source
Advanced Science, EarlyView.The dynamic disulfide bonds facilitated the development of high‐performance aerospace ablation‐resistant materials. At moderate temperature, the dissociation and recombination of disulfide bonds ensured excellent processability, mechanical properties, and recycling ability of phenolic resin; at high temperature, cleavage of disulfide bonds produced ...
Yu Li +9 more
wiley +1 more source
Stacking Pressure‐Driven Interfacial Dynamics in Anode‐Free Solid‐State Lithium Batteries
Advanced Science, EarlyView.Using a three‐electrode setup, it is found that stacking pressure improves both anode and cathode interfaces but more effectively stabilizes the anode. Under low pressure, a sudden anode resistance rise indicates contact loss. Higher pressure delays this via Li creep and plastic deformation, maintaining interfacial contact.
Jianneng Liang +8 more
wiley +1 more source
Advanced Electronic Materials, EarlyView.This review summarizes the developments in field‐effect transistor (FET)‐based dual‐mode sensor platforms and what can be learned from them. It identifies charge as a crucial factor in biomolecular interactions at interfaces, outlines the challenges of hybrid systems, and highlights their benefits.
Roger Hasler +4 more
wiley +1 more source