Results 81 to 90 of about 100,790 (231)

Accelerated cloning of a potato late blight–resistance gene using RenSeq and SMRT sequencing [PDF]

, 2016
Global yields of potato and tomato crops are reduced owing to potato late blight disease, which is caused by Phytophthora infestans. Although most commercial potato varieties are susceptible to blight, wild potato relatives are not and are therefore a ...
A Bankevich, A Konieczny, A Kumar, A Marchler-Bauer, AA Lokossou, Agnieszka I Witek, AJ Haverkort, B Steuernagel, CE Caten, D Maclean, D Sharon, David Baker, DGO Saunders, F Jupe, F Jupe, Florian Jupe, G Andolfo, G Rallapalli, H Li, J Eid, J Rodewald, J S´liwka, JD Thompson, JDG Jones, JDG Jones, JL Dangl, JL Dangl, Jonathan D G Jones, K Tamura, Kamil Witek, M Narusaka, M Stanke, M Wang, Matthew D Clark, MLK Manoko, PF Sarris, R Lebecka, R Lebecka, S Cesari, SF Altschul, SJ Foster, TL Bailey, X Jiao, X Xu, Š Baebler   +44 more
core   +1 more source

PROGRAMIRANA STANIČNA SMRT

, 2016
The goal of this review is to introduce the reader with basic mechanisms of apoptosis and the main functions of programmed cell death in multicellular organisms. Apoptosis is a programmed process of cell death accompanied by activation of caspases, cysteinyl aspartate – specific proteases.
openaire   +3 more sources

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system

The FEBS Journal, EarlyView.
The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger, Alice Wiedmann, Rayan Hassan M. Elshikhidriss, Thomas Brunner   +3 more
wiley   +1 more source

TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells [PDF]

, 2019
The epithelial-to-mesenchymal transition (EMT) and its reversion (MET) are related to tumor cell dissemination and migration, tumor circulating cell generation, cancer stem cells, chemoresistance, and metastasis formation.
García Martínez, Jorge, Guerrero Martínez, José A., Gómez Marín, Elena, Reyes Rosa, José Carlos, Rivero Canalejo, Sabrina   +4 more
core   +2 more sources

Structural Variations Contribute to Subspeciation and Yield Heterosis in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Yield heterosis has been extensively exploited in hybrid breeding, with intersubspecific hybrids often exhibiting the most pronounced effects. However, developing elite hybrids remains a laborious and time‐consuming process. The genetic basis of heterosis has been debated for over a century, hindered largely by the lack of high‐quality genomes.
Zhiwu Dan, Yunping Chen, Wenchao Huang
wiley   +1 more source

A Sequel to Sanger: amplicon sequencing that scales

BMC Genomics, 2018
Background Although high-throughput sequencers (HTS) have largely displaced their Sanger counterparts, the short read lengths and high error rates of most platforms constrain their utility for amplicon sequencing.
Paul D. N. Hebert, Thomas W. A. Braukmann, Sean W. J. Prosser, Sujeevan Ratnasingham, Jeremy R. deWaard, Natalia V. Ivanova, Daniel H. Janzen, Winnie Hallwachs, Suresh Naik, Jayme E. Sones, Evgeny V. Zakharov   +10 more
doaj   +1 more source

Jabba: hybrid error correction for long sequencing reads using maximal exact matches [PDF]

, 2015
Third generation sequencing platforms produce longer reads with higher error rates than second generation sequencing technologies. While the improved read length can provide useful information for downstream analysis, underlying algorithms are challenged
Audenaert, P., Demeester, Piet, Fostier, Jan, Heydari, Mahdi, Miclotte, Giles   +4 more
core   +1 more source

Multi‐Omics Insights Into Anthraquinone Biosynthesis in Rheum tanguticum

Plant Biotechnology Journal, EarlyView.
ABSTRACT Rheum tanguticum is renowned for its medicinal properties, including purgative, anti‐inflammatory and hepatoprotective effects, primarily attributed to anthraquinones (AQs). However, the molecular mechanisms of AQs biosynthesis have largely been hindered by insufficient genomic resources and functional genomics investigations.
Shuo Zhao, Yuan Zong, Tao Wang, Jianan Li, Zengrong Ye, Famei Zhang, Guoying Zhou   +6 more
wiley   +1 more source

Genomic and Transcriptomic Analyses Provide Insights Into Erysiphe necator Pathogenicity and Grapevine Response

Plant Biotechnology Journal, EarlyView.
ABSTRACT Grapevine powdery mildew, caused by the fungus Erysiphe necator, is one of the most prevalent obligate biotrophic pathogens in vineyards, posing a significant threat to grape production. Despite its impact, research on E. necator pathogenicity and grapevine responses remains limited.
Bo Mu, Ruixin Tang, Zhaolin Teng, Jinfu Chen, Kaicheng Cui, Feng Wei, Wenxiang Kong, Shunyuan Xiao, Xiangnan Xu, Jia‐Yue Feng, Ying‐Qiang Wen   +10 more
wiley   +1 more source