Results 1 to 10 of about 6,812 (127)

A new case of sodium‐dependent multivitamin transporter defect occurring as a life‐threatening condition responsive to early vitamin supplementation and literature review [PDF]

Molecular Genetics & Genomic Medicine
Background Biallelic pathogenic variants in SLC5A6 resulting in sodium‐dependent multivitamin transporter (SMVT) defect have recently been described as a vitamin‐responsive inborn error of metabolism mimicking biotinidase deficiency.
F.‐X. Van Vyve, N. Mercier, J. Papadopoulos, C. Heijmans, H. Dessy, O. Monestier, J. P. Dewulf, D. Roland   +7 more
doaj   +3 more sources

Biotin-mediated drug delivery: does the biotin transporter mediate uptake of biotin conjugates? [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Sodium-dependent multivitamin transporter (SMVT) is a biotin transporter over-expressed in various types of cancer cells and is commonly studied for targeted drug delivery using biotin conjugates.
Ravi Tripathi, Xiaoxiao Yang, Dongning Liu, Wen Lu, Binghe Wang   +4 more
doaj   +2 more sources

Management and outcome of different types of ventricular tachycardia associated with hypokalemia [PDF]

Heart Rhythm O2
Background: Hypokalemia is a potentially reversible cause of ventricular tachyarrhythmias (VTAs) such as polymorphic ventricular tachycardia/ventricular fibrillation (PMVT/VF) and sustained monomorphic ventricular tachycardia (SMVT).
Micaela Ebert, MD, Ines Masmoudi, MD, Mandy Flechsig, MD, Julia Mayer, MD, Stefan Ulbrich, MD, Leonhard Schleußner, MD, Thomas Gaspar, MD, Angela Zedda, MD, Axel Linke, MD, Sergio Richter, MD   +9 more
doaj   +2 more sources

Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)? [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Conjugation of drugs with biotin is a widely studied strategy for targeted drug delivery. The structure–activity relationship (SAR) studies through H3-biotin competition experiments conclude with the presence of a free carboxylic acid being essential for
Ravi Tripathi, Anchala Guglani, Rujuta Ghorpade, Binghe Wang   +3 more
doaj   +2 more sources

Non-revascularized chronic total occlusions impact on substrate and post-ablation results in drug-refractory electrical storm [PDF]

Frontiers in Cardiovascular Medicine, 2023
Background and aimsThere is limited data concerning the effect of non-revascularized chronic total occlusions (NR-CTOs) after VT ablation. This study sought to evaluate the impact of NR-CTOs after ablation for electrical storm (ES).MethodsPost-hoc ...
Cosmin Cojocaru, Cosmin Cojocaru, Alexandrina Nastasa, Stefan Bogdan, Stefan Bogdan, Corneliu Iorgulescu, Alexandru Deaconu, Alexandru Deaconu, Sebastian Onciul, Sebastian Onciul, Radu Vatasescu, Radu Vatasescu   +11 more
doaj   +2 more sources

Uptake of biotin by Chlamydia Spp. through the use of a bacterial transporter (BioY) and a host-cell transporter (SMVT). [PDF]

PLoS ONE, 2012
Chlamydia spp. are obligate intracellular Gram-negative bacterial pathogens that cause disease in humans and animals. Minor variations in metabolic capacity between species have been causally linked to host and tissue tropisms.
Derek J Fisher, Reinaldo E Fernández, Nancy E Adams, Anthony T Maurelli   +3 more
doaj   +4 more sources

Human Embryonic Kidney HEK293 Cells as a Model to Study SMVT-Independent Transport of Biotin and Biotin-Furnished Nanoparticles in Targeted Therapy. [PDF]

Int J Mol Sci
The aim of this study was to investigate the usefulness of human embryonic kidney HEK293 cells as a model of normal cells in biotin-mediated therapy. The expression and role of sodium multivitamin transporter (SMVT) in the uptake and accumulation of free biotin, as well as cationic and neutral biotinylated PAMAM dendrimers of the fourth generation ...
Twardowska M, Łyskowski A, Misiorek M, Szymaszek Ż, Wołowiec S, Dąbrowska M, Uram Ł.   +6 more
europepmc   +3 more sources

The Importance of Biotinylation for the Suitability of Cationic and Neutral Fourth-Generation Polyamidoamine Dendrimers as Targeted Drug Carriers in the Therapy of Glioma and Liver Cancer [PDF]

Molecules
In this study, we hypothesized that biotinylated and/or glycidol-flanked fourth-generation polyamidoamine (PAMAM G4) dendrimers could be a tool for efficient drug transport into glioma and liver cancer cells.
Łukasz Uram, Magdalena Twardowska, Żaneta Szymaszek, Maria Misiorek, Andrzej Łyskowski, Zuzanna Setkowicz, Zuzanna Rauk, Stanisław Wołowiec   +7 more
doaj   +2 more sources

Characterization of the Sodium Multi-Vitamin Transporter in the Mosquito Anopheles stephensi and Its Capacity to Mobilize Pantothenate and Biotin [PDF]

Biomolecules
Pantothenate (Pan), or vitamin B5, is essential for the synthesis of co-enzyme A (CoA), acetyl-CoA, and numerous downstream physiological processes.
Jun Isoe, Brendan F. Riske, Megan E. Dobson, Hannah L. Kaylor, Jessica C. Brady, Yared Debebe, Laura M. Saavedra, Shirley Luckhart, Michael A. Riehle   +8 more
doaj   +2 more sources

MSA-VT Score for Assessment of Long-Term Prognosis after Electrical Storm Ablation [PDF]

Biomedicines
Introduction: Prognosis after electrical storm (ES) ablation remains severe, especially in patients with recurrent sustained monomorphic ventricular tachycardia (SMVT) or progressive heart failure (HF).
Radu Vatasescu, Cosmin Cojocaru, Viviana Gondos, Corneliu Iorgulescu, Stefan Bogdan, Sebastian Onciul, Antonio Berruezo   +6 more
doaj   +2 more sources