Results 111 to 120 of about 6,812 (127)

Biotin Uptake by Rabbit Corneal Epithelial Cells: Role of Sodium-Dependent Multivitamin Transporter (SMVT)

Current Eye Research, 2006
The objective of this research was to investigate the presence of sodium-dependent multivitamin transporter (SMVT) on rabbit corneal epithelial cells.Primary cultured rabbit corneal epithelial cells (rPCECs)and freshly excised rabbit corneas were used for characterization of biotin uptake and transport, respectively.
Kumar G, Janoria, Sudharshan, Hariharan, Durga, Paturi, Dhananjay, Pal, Ashim K, Mitra   +4 more
openaire   +2 more sources

Biotin uptake by T47D breast cancer cells: Functional and molecular evidence of sodium-dependent multivitamin transporter (SMVT)

International Journal of Pharmaceutics, 2013
The objective of this study was to investigate functional and molecular evidence of carrier mediated system responsible for biotin uptake in breast cancer (T47D) cells and to delineate mechanism of intracellular regulation of this transporter. Cellular accumulation of [3H] biotin was studied in T47D and normal mammary epithelial (MCF-12A) cells ...
Aswani Dutt, Vadlapudi, Ramya Krishna, Vadlapatla, Dhananjay, Pal, Ashim K, Mitra   +3 more
openaire   +2 more sources

Blood-to-retina transport of biotin via Na+-dependent multivitamin transporter (SMVT) at the inner blood-retinal barrier

Experimental Eye Research, 2010
The purpose of this study was to elucidate the mechanisms of biotin transport across the inner blood-retinal barrier (inner BRB). [(3)H]Biotin transport in the retina across the inner BRB was examined using an in vivo integration plot and retinal uptake index analyses in rats. The transport mechanism was characterized using a conditionally immortalized
Yumiko, Ohkura, Shin-ichi, Akanuma, Masanori, Tachikawa, Ken-ichi, Hosoya   +3 more
openaire   +2 more sources

Targeting the Sodium-Dependent Multivitamin Transporter (SMVT) for Improving the Oral Absorption Properties of a Retro-Inverso Tat Nonapeptide

Pharmaceutical Research, 2001
To investigate the potential for delivering large peptides orally by altering their absorptive transport pathways and improving intestinal permeability. The absorptive transport of retro-inverso (R.I.-) K-Tat9 and R.I.-K(biotin)-Tat9, novel peptidic inhibitors of the Tat protein of HIV-1, and their interactions with human SMVT (hSMVT), a high affinity,
S, Ramanathan, S, Pooyan, S, Stein, P D, Prasad, J, Wang, M J, Leibowitz, V, Ganapathy, P J, Sinko   +7 more
openaire   +2 more sources

Biotinylated PAMAM dendrimers for intracellular delivery of cisplatin to ovarian cancer: role of SMVT.

Anticancer research, 2011
The aim of this study was to prepare biotinylated PAMAM dendrimers loaded with cisplatin and to evaluate the cytotoxicity in ovarian cancer cell lines.Biotinylated and unconjugated dendrimer-cisplatin complexes were investigated for encapsulation efficiency, in vitro cytotoxic activity and cellular accumulation of cisplatin in OVCAR-3, SKOV-3, A2780 ...
Venkata K, Yellepeddi, Ajay, Kumar, Diane M, Maher, Subhash C, Chauhan, Kiran K, Vangara, Srinath, Palakurthi   +5 more
openaire   +1 more source

Biotin/pantothenic acid over‐supplementation to SLC5A6 knockout (SMVT‐cKO) mice leads to normalization of the growth rate, intestinal mucosal morphology, and tight junction integrity of the knockout animals

The FASEB Journal, 2017
We have recently shown that intestinal‐specific(conditional) knockout of mouse SLC5A6 gene (which encodes sodium‐dependent multivitamin transporter, SMVT) leads to severe inhibition in intestinal biotin absorption, biotin deficiency and growth retardation.
Subrata Sabui, Nils W Lambrecht, Rubina Kapadia, Abhisek Ghosal, Hamid Said   +4 more
openaire   +1 more source

Development and implementation of a guideline-based decision support system for etiological diagnosis of Sustained Monomorphic Ventricular Tachycardia (SMVT)

European Heart Journal
Abstract Background Guideline (GL)-based decision support systems (DSSs) play a significant role in supporting physicians in their decision-making processes by providing structured clinical guidance. While these systems have shown significant success in enhancing practitioner performance and patient ...
S Zheng, X W Xu, Z Hu, M Wang, Y Yao, J Li   +5 more
openaire   +1 more source

Spontaneous superior mesenteric vein thrombosis (SMVT) in primary protein S deficiency. A case report and review of the literature.

Chirurgia italiana, 2000
Superior mesenteric vein thrombosis (SMVT) is an uncommon but important clinical entity that can induce ischemia or infarction of the small and large bowel. It is rare and accounts for 5-15% of mesenteric vascular occlusions. Bowel infarction due to SMVT can present as an acute abdominal disease, requiring urgent laparotomy with resection of the ...
L, Bonariol, C, Virgilio, E, Tiso, M, Biral, C, Mascarin, E, Mingardi, M, Pozzobon, R, Zennari, F, Sandei   +8 more
openaire   +1 more source

Radiofrequency Ablation without ICD Effective and Safe for Well-Tolerated SMVT

MD Conference Express, 2013
T. Rizzo, P. Maury
openaire   +1 more source

Studies on the role of WW-PLEKHAs in regulating the localization of the calcium pump PMCA and the sodium-dependent multivitamin transporter (SMVT)

2022
Calcium homeostasis plays a major role in cellular physiology, and its dysregulation can lead to cell death. The Plasma Membrane Calcium ATPase (PMCA) plays a key role in calcium efflux from the cytosol towards the extracellular space to terminate calcium signaling.
openaire   +1 more source