Results 171 to 180 of about 51,969 (259)

Hyperactive KIF5A in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT The highly polarised morphology of neurons and the sheer length of their axons make transport of cargoes throughout the cell a formidable task. Decades of evidence obtained from genetic studies on patients and animal models highlight deficits in axonal transport as a recurrent cause, or early contributing factor, in a plethora of ...
David Villarroel‐Campos, James N. Sleigh   +1 more
wiley   +1 more source

From Pellets to Snacks: Effects of Deep-Frying and Microwave Heating on Polyphenols, Physicochemical Properties and Sensory Profiles of Mushroom-Enriched Snacks. [PDF]

Molecules
Nemś A, Kolniak-Ostek J, Michalska-Ciechanowska A, Gryszkin A, Kita A.   +4 more
europepmc   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Impact of Food and Beverage on Enlicitide Pharmacokinetics and LDL‐C Lowering

Clinical Pharmacology &Therapeutics, EarlyView.
Enlicitide decanoate is a macrocyclic peptide first‐in‐class oral PCSK9 inhibitor that lowers LDL‐C, with maximal efficacy achieved when administered on an empty stomach. This work characterizes the effects of food, pre‐dose fasting duration (2–8 hours), water volume, common beverages (black coffee and plain tea), and other real‐world scenarios on ...
Douglas G. Johns, Maja Skataric, Susan Zhou, Ferdous Gheyas, Ednan Bajwa, Puja Banka, Filippos Kesisoglou, Allen Hunt, David Bruce, Corey Anderson, Helen Manthos, Jonathan Pollock, Paul J. Donabella, Campbell Thompson, Daniel Freire, Kiet Giang, Frank Pietrantonio, Dennis Wolford, Piyali Basak, Maxwell Pistilli, Bhavna Kantesaria, Prajakti Kothare, Islam R. Younis   +22 more
wiley   +1 more source

Implementation of Pharmacogenomics in Pediatric‐Focused Institutions Within the Pharmacogenomics Global Research Network

Clinical Pharmacology &Therapeutics, EarlyView.
Descriptions of how pediatric‐focused institutions implement pharmacogenomic testing are scarce, and often not differentiated from adult‐focused institutions. We aimed to provide a detailed description of how pediatric‐focused institutions across the world implemented pharmacogenomic testing in clinical practice.
Laura B. Ramsey, Chad Bousman, Rebecca Brand, Kelsey Cook, David B. Gregornik, Cyrine E. Haidar, Nancy Hakooz, Nicole Keuler, Nathan Lamb, Mohamed Nagy, Jenny Q. Nguyen, Courtney Paetznick, April Schultz, D. Max Smith, Evangelia Eirini Tsermpini, Amanda L. Elchynski   +15 more
wiley   +1 more source

Harmonizing Social Impact Assessment in the Bioeconomy: A Cross‐Regional Fuzzy‐Delphi Approach

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The bioeconomy transition risks underrepresenting social sustainability, while existing Social Life Cycle Assessment (S‐LCA) applications remain insufficient for comparison and decision support due to heterogeneous and non‐standardized selection of social impact categories. This study proposes a cross‐regional baseline set of impact categories
Julia Lessa Feitosa Virgolino, Claudia Coutinho‐Nóbrega, Nicholas M. Holden   +2 more
wiley   +1 more source

Exercise Snacks Are Feasible to Perform in the Real World and Improve Physical Capacity for Adults Living With Non-Insulin Treated Type 2 Diabetes: A Randomised Trial. [PDF]

Diabetes Obes Metab
Babir FJ, Marcotte-Chénard A, Sandilands RE, Falkenhain K, Mulkewich N, Islam H, McCarthy SF, Richards DL, Madden K, Singer J, Riddell MC, Jung ME, Gibala MJ, Little JP.   +13 more
europepmc   +1 more source

Bridging Collaboration and Sustainability: The Role of Digital Strategy at the Organizational Level

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Supply chain management research indicates that collaborations should be explored from both the demand and supply perspectives. To accomplish this, the present paper investigates the relations among collaborative performance management, digital strategy, and sustainability performance in the Finnish construction industry.
Minna Saunila, Juhani Ukko, Jorma Kinnunen   +2 more
wiley   +1 more source

Effects of Stair-Climbing Exercise Snacks with Blood Flow Restriction on Fitness in Sedentary University Students: A Pilot Randomized Controlled Trial. [PDF]

Life (Basel)
Qiu L, Liang J, Yu L, Gao S, Tan Y, Li X, Gan J.   +6 more
europepmc   +1 more source

Curriculum alignment with international graduate attribute standards in engineering education: The CPUT experience

The Curriculum Journal, EarlyView.
Abstract This paper presents a qualitative case study of how the Mechanical Engineering Diploma programme at Cape Peninsula University of Technology (CPUT) systematically aligned its curriculum with both national and international graduate attribute (GA) standards.
Ali Rugbani, Simphiwe Nqabisa
wiley   +1 more source