Results 161 to 170 of about 106,824 (308)

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa   +9 more
wiley   +1 more source

Oxidative Damage, Energy Imbalance, and Behavioral Disruptions in Girardia tigrina Exposed to Treated Sewage Effluents

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT This study assessed the ecotoxicological effects of treated sewage on the freshwater planarian Girardia tigrina, integrating biochemical, energetic, and behavioral biomarkers. Planarians were exposed for 48 h to different concentrations of treated sewage (12.5%, 25%, 50%, and 100%) and compared to controls using commercial water and water from
Renata M. P. Freitas   +3 more
wiley   +1 more source

Enhancement of immune checkpoint inhibitor efficacy by DHX58+ SELL+ T cells in advanced gastric cancer

open access: yesVIEW, EarlyView.
We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen   +9 more
wiley   +1 more source

Checking Snails – pupils as snail watchers

open access: yesFrontiers in Environmental Science, 2016
Jaksch Katharina   +3 more
openaire   +1 more source

PPM1G‒MET axis sustains AKT signaling to drive Twist‐associated EMT and drug resistance in hepatocellular carcinoma

open access: yesVIEW, EarlyView.
Hepatocellular carcinoma (HCC) is frequently resistant to targeted therapies. We identify protein phosphatase Mg2+/Mn2+‐dependent 1G (PPM1G) as a key phosphatase that stabilizes mesenchymal‐epithelial transition factor (MET) by inhibiting its ubiquitination, thereby sustaining protein kinase B (AKT) signaling and promoting Twist‐mediated epithelial ...
Weixun Wu   +8 more
wiley   +1 more source

Biomphalaria pfeifferi infected with Schistosoma spp. in Kakamega and Bungoma counties, western Kenya confirms autochthonous transmission of intestinal schistosomiasis. [PDF]

open access: yesPLoS Negl Trop Dis
Odiere MR   +11 more
europepmc   +1 more source

Delisting the Northern Rocky Mountain gray wolf from the US Endangered Species Act: an assessment of political discourse over 20 years

open access: yesWildlife Biology, EarlyView.
Feared, revered, and politicized, wolves have long captured human imagination, and ignited fierce conservation conflicts. In the United States, the Endangered Species Act protects species at risk of extinction from human impacts. This far‐reaching legislation, which impacts development and state‐level wildlife management, has been fraught with legal ...
Iree Wheeler   +9 more
wiley   +1 more source

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