Results 1 to 10 of about 75,123 (237)

Interrogating the Venom of the Viperid Snake Sistrurus catenatus edwardsii by a Combined Approach of Electrospray and MALDI Mass Spectrometry. [PDF]

PLoS ONE, 2015
The complete sequence characterization of snake venom proteins by mass spectrometry is rather challenging due to the presence of multiple isoforms from different protein families.
Alex Chapeaurouge, Md Abu Reza, Stephen P Mackessy, Paulo C Carvalho, Richard H Valente, André Teixeira-Ferreira, Jonas Perales, Qingsong Lin, R Manjunatha Kini   +8 more
doaj   +8 more sources

Snake Venom Protease Detection and Inhibition in Serum. [PDF]

ChemMedChem
A fluorescence assay enables sensitive detection of the activities of snake venom metalloproteases (SVMP) and serine proteases (SVSP) from viper venoms in buffer and serum. In combination with effective low‐molecular‐weight inhibitors such as ilomastat and nafamostat, this approach offers new prospects for the rapid diagnosis and adjunctive therapy of ...
Riedel M, Kersten C.
europepmc   +2 more sources

Innovations in Snake Venom-Derived Therapeutics: A Systematic Review of Global Patents and Their Pharmacological Applications [PDF]

Toxins
Active compounds from natural sources, particularly snake venoms, are crucial for pharmaceutical development despite challenges in drug discovery. Snake venoms, historically used for medicinal purposes, contain bioactive peptides and enzymes that show ...
Diana Carolina Zona Rubio, Diana Marcela Aragón, Izabel Almeida Alves   +2 more
doaj   +2 more sources

Emerging Trends in Snake Venom-Loaded Nanobiosystems for Advanced Medical Applications: A Comprehensive Overview [PDF]

Pharmaceutics
Advances in medical nanobiotechnology have notably enhanced the application of snake venom toxins, facilitating the development of new therapies with animal-derived toxins.
Álisson E. F. Alves, Anne B. C. Barros, Lindomara C. F. Silva, Lucas M. M. Carvalho, Graziela M. A. Pereira, Ana F. C. Uchôa, José M. Barbosa-Filho, Marcelo S. Silva, Karla P. O. Luna, Karla S. R. Soares, Francisco H. Xavier-Júnior   +10 more
doaj   +2 more sources

Description of the antipredatory head-wobble behaviour in Chilean rear-fanged snakes Tachymenis peruviana Wiegmann, 1835 and Tachymenis chilensis coronellina Werner, 1898 (Serpentes, Dipsadidae) [PDF]

Herpetozoa, 2022
In this work, we describe the first records of head-wobble behaviour for Tachymenis peruviana and T. chilensis coronellina. We analyse this behaviour (occurrence, frequency) and accompanying displays in both species. Of particular note is that T.
Claudio Reyes-Olivares, Alex Vera-Quispe, Alejandro Zúñiga, Félix A. Urra   +3 more
doaj   +3 more sources

First record of the invasive gecko, Lepidodactylus lugubris Duméril & Bibron, 1836 in mainland Chile (Squamata, Gekkonidae) [PDF]

Herpetozoa, 2020
In Chile, the presence of Mourning Gecko, Lepidodactylus lugubris Duméril & Bibron, 1836 has been recognized for Easter Island (Rapa Nui) from late 19th century. Here, we report the first observation of a juvenile specimen of L.
Felix A. Urra, Alejandro Zúñiga, Alejandro Bruno Miranda-Calle, Nel Melero   +3 more
doaj   +3 more sources

Extracellular Matrix Signals as Drivers of Mitochondrial Bioenergetics and Metabolic Plasticity of Cancer Cells During Metastasis

Frontiers in Cell and Developmental Biology, 2021
The role of metabolism in tumor growth and chemoresistance has received considerable attention, however, the contribution of mitochondrial bioenergetics in migration, invasion, and metastasis is recently being understood.
Félix A. Urra, Félix A. Urra, Sebastián Fuentes-Retamal, Sebastián Fuentes-Retamal, Charlotte Palominos, Charlotte Palominos, Yarcely A. Rodríguez-Lucart, Yarcely A. Rodríguez-Lucart, Camila López-Torres, Camila López-Torres, Ramiro Araya-Maturana, Ramiro Araya-Maturana   +11 more
doaj   +1 more source

Pictolysin-III, a Hemorrhagic Type-III Metalloproteinase Isolated from Bothrops pictus (Serpentes: Viperidae) Venom, Reduces Mitochondrial Respiration and Induces Cytokine Secretion in Epithelial and Stromal Cell Lines

Pharmaceutics, 2023
From the venom of the Bothrops pictus snake, an endemic species from Peru, we recently have described toxins that inhibited platelet aggregation and cancer cell migration.
Dan E. Vivas-Ruiz, Paola Rosas, Alex Proleón, Daniel Torrejón, Fanny Lazo, Ana Belén Tenorio-Ricca, Francisco Guajardo, Cristopher Almarza, Víctor Andrades, Jessica Astorga, Daniel Oropesa, Jorge Toledo, María Jesús Vera, Jorge Martínez, Ramiro Araya-Maturana, Karen Dubois-Camacho, Marcela A. Hermoso, Valéria G. Alvarenga, Eladio Flores Sanchez, Armando Yarlequé, Luciana Souza Oliveira, Félix A. Urra   +21 more
doaj   +1 more source

An Emergent Role for Mitochondrial Bioenergetics in the Action of Snake Venom Toxins on Cancer Cells

Frontiers in Oncology, 2022
Beyond the role of mitochondria in apoptosis initiation/execution, some mitochondrial adaptations support the metastasis and chemoresistance of cancer cells. This highlights mitochondria as a promising target for new anticancer strategies.
Félix A. Urra, Félix A. Urra, Félix A. Urra, Dan E. Vivas-Ruiz, Dan E. Vivas-Ruiz, Eladio Flores Sanchez, Eladio Flores Sanchez, Ramiro Araya-Maturana, Ramiro Araya-Maturana, Ramiro Araya-Maturana   +9 more
doaj   +1 more source

Leucism and albinism in the rear-fanged snakes Tachymenis chilensis chilensis (Schlegel, 1837) and Tachymenis chilensis coronellina Werner, 1898 (Serpentes, Dipsadidae) [PDF]

Herpetozoa, 2021
Herein, we report the first observation of two different coloration patterns in Chilean snakes. Based on the alteration of wild coloration patterns, a juvenile specimen of Tachymenis chilensis coronellina Werner, 1898 was diagnosed with albinism and a ...
Felix A. Urra, Alejandro Zúñiga, Nel Melero, Nibaldo Reyes, Yarela Herrera, Alejandro Bruno Miranda-Calle, Juan Carlos Ortiz   +6 more
doaj   +3 more sources