Results 21 to 30 of about 205,653 (257)

Optimal Trajectory Scheme for Robotic Welding Along Complex Joints Using a Hybrid Multi-Objective Genetic Algorithm

IEEE Access, 2019
The problem of trajectory planning is relevant for the proper use of costly robotic systems to mitigate undesirable effects such as vibration and even wear on the mechanical structure of the system.
John Ogbemhe, Khumbulani Mpofu, Nkgatho Tlale   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Context-aware prediction of active and passive user engagement: Evidence from a large online social platform

Journal of Big Data
The success of online social platforms hinges on their ability to predict and understand user behavior at scale. Here, we present data suggesting that context-aware modeling approaches may offer a holistic yet lightweight and potentially privacy ...
Heinrich Peters, Yozen Liu, Francesco Barbieri, Raiyan Abdul Baten, Sandra C. Matz, Maarten W. Bos   +5 more
doaj   +1 more source

Contribution of remote sensing and GIS in the study of the evolution of Anza beach in Agadir (Morocco) [PDF]

E3S Web of Conferences
The Moroccan coastline, in particular the Atlantic coast, presents a unique geographical and environmental context that requires special attention.
Bouhadi Amine, Ben harra Abdessalam, Elallati Samia, Falouss Safae, issa Lamiae Khali, Idmhand Youssef, Raissouni Ahmed, El arrim Abdlekrim   +7 more
doaj   +1 more source

Solanum nigrum induces macrophage activation through TLR4-mediated activation of JNK and macrophage autophagy through TLR4-mediated activation of p38 and JNK

Food and Agricultural Immunology, 2022
In this study, we investigated the effect of Solanum nigrum aerial parts (SNAP) on macrophage activation and macrophage autophagy in RAW264.7 cells. SNAP increased the production of immunostimulatory factors and phagocytosis in RAW264.7 cells.
Ju Hyung Yu, Min Yeong Choi, So Jung Park, Na Gyeong Geum, Jae Won Lee, Gwang Hun Park, Hyun Ji Eo, Jin Boo Jeong   +7 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Benefits of a snap-joint system in an immediate full-arch maxillary fixed rehabilitation on disparallel implants [PDF]

Exploration of Medicine
Immediate implant-supported rehabilitation of atrophic maxillae with a fixed screw-retained prosthesis has to deal with the fixtures’ disparallelism and a high risk of fracture of the fixture-abutment connecting screw. After the flapless placement of six
Gerardo Pellegrino, Zoran Zaccheroni, Vittorio Checchi, Giuseppe Lizio   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Suffering, the Safety Net, and Disparities During COVID-19

RSF: The Russell Sage Foundation Journal of the Social Sciences, 2023
The economic and public health crisis caused by COVID-19 was devastating and disproportionately hurt Blacks and Hispanics and some other groups. Unemployment rates and other measures of material hardship were higher and increased more during the crisis ...
Marianne P. Bitler, Hilary W. Hoynes, Diane Whitmore Schanzenbach   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source