Advanced Science, EarlyView.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
The Hidden Cost of Overfishing To Commercial Fishermen: A 2009 Snapshot of Lost Revenues [PDF]
, 2011 Ocean fish populations are a vital renewable resource for human populations, providing food,employment and recreation, as well as contributing to global biodiversity.
Taylor Hesselgrave
core
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Advanced Science, EarlyView.Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Otolith chemistry, stomach contents and stable isotope analysis of a snapper (Pagrus auratus) caught in the Waikato River at Ngaruawahia [PDF]
, 2009 Analyses of stomach contents, stable isotopes and otolith microchemistry were carried out in order to ascertain the length of freshwater residence of a snapper (Pagrus auratus) caught in the Waikato River at Ngaruawahia in a net set for grey mullet(Mugil
Blair, Jennifer Marie, Hicks, Brendan J.
core +1 more source
Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy
Advanced Science, EarlyView.A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann +15 more
wiley +1 more source
Testing Potential Fish Fraud in Community-Supported Fisheries [PDF]
, 2016 The seafood industry has long been plagued by the substitution of a species under a false label. Seafood mislabeling is a major concern in the management of fish and marine species.
Tartre, Ryan J
core +1 more source
Scissors as a propofol ampoule ‘snapper’? [PDF]
Anaesthesia, 1999 K, Koga, M, Hirose
openaire +2 more sources
Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease
Advanced Science, EarlyView.ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan +17 more
wiley +1 more source
Extending the Bajo de Sico, Puerto Rico, Seasonal Closure: An Examination of Small-scale Fishermen’s Perceptions of Possible Socio-economic Impacts on Fishing Practices, Families, and Community [PDF]
, 2009 Despite considerable conservation efforts, many reef fish fisheries around the world continue to be in peril. Many are vulnerable to overexploitation because they have predictable and highly aggregated spawning events. In U.S.
Agar, Juan J., Tonioli, Flavia C.
core
Advanced Science, EarlyView.This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin +12 more
wiley +1 more source