Results 141 to 150 of about 15,041 (173)
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification
CellSmall nucleolar RNAs (snoRNAs) are non-coding RNAs known for guiding RNA modifications, including 2'-O-methylation (Nm) and pseudouridine (Ψ). While snoRNAs may also interact with other RNAs, such as mRNA, the full repertoire of RNAs targeted by snoRNA remains elusive due to the lack of effective technologies that identify snoRNA targets transcriptome ...
Yuhao Zhong
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Biochimie, 2002
In eukaryotes, the site-specific formation of the two prevalent types of rRNA modified nucleotides, 2'-O-methylated nucleotides and pseudouridines, is directed by two large families of snoRNAs. These are termed box C/D and H/ACA snoRNAs, respectively, and exert their function through the formation of a canonical guide RNA duplex at the modification ...
Jérôme Cavaille +2 more
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In eukaryotes, the site-specific formation of the two prevalent types of rRNA modified nucleotides, 2'-O-methylated nucleotides and pseudouridines, is directed by two large families of snoRNAs. These are termed box C/D and H/ACA snoRNAs, respectively, and exert their function through the formation of a canonical guide RNA duplex at the modification ...
Jérôme Cavaille +2 more
exaly +3 more sources
Are snoRNAs and snoRNA host genes new players in cancer?
Nature Reviews Cancer, 2012Small nucleolar RNAs (snoRNAs) have long been considered important but unglamorous elements in the production of the protein synthesis machinery of the cell. Recently, however, several independent lines of evidence have indicated that these non-coding RNAs might have crucial roles in controlling cell behaviour, and snoRNA dysfunction could consequently
Williams, Gwyn T., Farzaneh, Farzin
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The snoRNA box C/D motif directs nucleolar targeting and also couples snoRNA synthesis and localization [PDF]
EMBO Journal, 1998 Most small nucleolar RNAs (snoRNAs) fall into two families, known as the box C/D and box H/ACA snoRNAs. The various box elements are essential for snoRNA production and for snoRNA-directed modification of rRNA nucleotides. In the case of the box C/D snoRNAs, boxes C and D and an adjoining stem form a vital structure, known as the box C/D motif.
Robert H. Singer +2 more
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A novel snoRNA gene cluster in yeast is transcribed as polycistronic pre-snoRNAs
Science in China Series C: Life Sciences, 1999Small nucleolar RNAs (snoRNAs) play an important role in eukaryotic rRNA biogenesis. By combination of a computer search of EMBL database and experimental procedure, a novel snoRNA coding sequence (Z8) was screened out and characterized from yeastSaccharomyces cerevisiue genome.
Y, Lu, H, Zhou, W, Zhou, Y, Zhu, L, Qu
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snoRNAs contribute to myeloid leukaemogenesis
Nature Cell Biology, 2017The mechanism of action of oncogenes in acute myeloid leukaemia is poorly understood. A study now shows that the fusion oncoprotein AML1-ETO regulates leukaemogenesis by increasing the expression of small nucleolar RNAs through post-transcriptional mechanisms, resulting in increased ribosomal RNA methylation, protein translation, and promotion of ...
Mona, Khalaj, Christopher Y, Park
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snoRNAs in making “snoman” ribosomes
Molecular CellIn a recent study in Cell, Cheng and Wang et al.1 show that the small nucleolar RNA (snoRNA) SNORA13 has a non-canonical role in ribosome biogenesis and senescence by acting directly on RPL23 and regulating its assembly into the 60S ribosomal subunit.
Adrianna, Dabrowska, Davide, Ruggero
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Nature Genetics, 2008
A new paper reports an individual with the major features of Prader-Willi syndrome (PWS) and a microdeletion in 15q11–q13 removing a cluster of small nucleolar RNAs (snoRNAs). This report provides virtually conclusive evidence that PWS is caused by loss of expression of the C/D box HBII-85 snoRNAs.
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A new paper reports an individual with the major features of Prader-Willi syndrome (PWS) and a microdeletion in 15q11–q13 removing a cluster of small nucleolar RNAs (snoRNAs). This report provides virtually conclusive evidence that PWS is caused by loss of expression of the C/D box HBII-85 snoRNAs.
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Science, 2011
Covalent addition of methyl groups regulates the function of a number of proteins, including histones. The carboxy-terminal domain (CTD) of RNA Polymerase II (RNAPII) is made up of 7-mer repeats, and their site-specific phosphorylation results in the recruitment of regulators to the transcription complex. Sims et al. (p.
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Covalent addition of methyl groups regulates the function of a number of proteins, including histones. The carboxy-terminal domain (CTD) of RNA Polymerase II (RNAPII) is made up of 7-mer repeats, and their site-specific phosphorylation results in the recruitment of regulators to the transcription complex. Sims et al. (p.
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Molecular Evolution of the HBII-52 snoRNA Cluster
Journal of Molecular Biology, 2008HBII-52 is a human brain-specific C/D box snoRNA that potentially regulates the editing and/or alternative splicing of the serotonin receptor. Forty-two nearly identical copies of the HBII-52 gene are located immediately downstream of the SNRPN protein-coding gene in an imprinted locus associated with Prader-Willi syndrome.
Nahkuri, S. +3 more
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