Results 191 to 200 of about 15,243 (207)
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Biochimie, 2002
In eukaryotes, the site-specific formation of the two prevalent types of rRNA modified nucleotides, 2'-O-methylated nucleotides and pseudouridines, is directed by two large families of snoRNAs. These are termed box C/D and H/ACA snoRNAs, respectively, and exert their function through the formation of a canonical guide RNA duplex at the modification ...
Jean Pierre, Bachellerie +2 more
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In eukaryotes, the site-specific formation of the two prevalent types of rRNA modified nucleotides, 2'-O-methylated nucleotides and pseudouridines, is directed by two large families of snoRNAs. These are termed box C/D and H/ACA snoRNAs, respectively, and exert their function through the formation of a canonical guide RNA duplex at the modification ...
Jean Pierre, Bachellerie +2 more
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Are snoRNAs and snoRNA host genes new players in cancer?
Nature Reviews Cancer, 2012Small nucleolar RNAs (snoRNAs) have long been considered important but unglamorous elements in the production of the protein synthesis machinery of the cell. Recently, however, several independent lines of evidence have indicated that these non-coding RNAs might have crucial roles in controlling cell behaviour, and snoRNA dysfunction could consequently
Williams, Gwyn T., Farzaneh, Farzin
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snoRNAs contribute to myeloid leukaemogenesis
Nature Cell Biology, 2017The mechanism of action of oncogenes in acute myeloid leukaemia is poorly understood. A study now shows that the fusion oncoprotein AML1-ETO regulates leukaemogenesis by increasing the expression of small nucleolar RNAs through post-transcriptional mechanisms, resulting in increased ribosomal RNA methylation, protein translation, and promotion of ...
Mona, Khalaj, Christopher Y, Park
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A novel snoRNA gene cluster in yeast is transcribed as polycistronic pre-snoRNAs
Science in China Series C: Life Sciences, 1999Small nucleolar RNAs (snoRNAs) play an important role in eukaryotic rRNA biogenesis. By combination of a computer search of EMBL database and experimental procedure, a novel snoRNA coding sequence (Z8) was screened out and characterized from yeastSaccharomyces cerevisiue genome.
Y, Lu, H, Zhou, W, Zhou, Y, Zhu, L, Qu
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snoRNAs in making “snoman” ribosomes
Molecular CellIn a recent study in Cell, Cheng and Wang et al.1 show that the small nucleolar RNA (snoRNA) SNORA13 has a non-canonical role in ribosome biogenesis and senescence by acting directly on RPL23 and regulating its assembly into the 60S ribosomal subunit.
Adrianna, Dabrowska, Davide, Ruggero
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Differential expression of human 5S snoRNA genes
Biochemical and Biophysical Research Communications, 2002Four novel small nucleolar RNAs (snoRNAs), h5sn1, h5sn2, h5sn3, and h5sn4, were successfully amplified from human total RNAs using RT-PCR. They exhibited the structural hallmarks of box H/ACA snoRNAs and formed sequence complementarity to 5S rRNA. The nucleotide sequences of the snoRNAs from different donors were highly conserved as evidenced by single-
Long Sen, Chang +3 more
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Nature Genetics, 2008
A new paper reports an individual with the major features of Prader-Willi syndrome (PWS) and a microdeletion in 15q11–q13 removing a cluster of small nucleolar RNAs (snoRNAs). This report provides virtually conclusive evidence that PWS is caused by loss of expression of the C/D box HBII-85 snoRNAs.
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A new paper reports an individual with the major features of Prader-Willi syndrome (PWS) and a microdeletion in 15q11–q13 removing a cluster of small nucleolar RNAs (snoRNAs). This report provides virtually conclusive evidence that PWS is caused by loss of expression of the C/D box HBII-85 snoRNAs.
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Science, 2011
Covalent addition of methyl groups regulates the function of a number of proteins, including histones. The carboxy-terminal domain (CTD) of RNA Polymerase II (RNAPII) is made up of 7-mer repeats, and their site-specific phosphorylation results in the recruitment of regulators to the transcription complex. Sims et al. (p.
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Covalent addition of methyl groups regulates the function of a number of proteins, including histones. The carboxy-terminal domain (CTD) of RNA Polymerase II (RNAPII) is made up of 7-mer repeats, and their site-specific phosphorylation results in the recruitment of regulators to the transcription complex. Sims et al. (p.
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Peroxiredoxin 1 post-transcriptionally regulates snoRNA expression
Free Radical Biology and Medicine, 2019Peroxiredoxin 1 (Prx1) is a member of the Prx family that detoxifies various peroxide substrates through conserved catalytic cysteine residues with the use of reducing equivalents. In addition to this well-known role of Prx1, we have previously demonstrated that Prx1 also has RNA-binding properties, but its function as an RNA-binding protein (RBP ...
Eun-Kyung, Kim +4 more
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