Results 171 to 180 of about 912,053 (206)

SNP Arrays for Species Identification in Salmonids

2016
The use of SNP genotyping microarrays, developed in one species to analyze a closely related species for which genomic sequence information is scarce, enables the rapid development of a genomic resource (SNP information) without the need to develop new species-specific markers.
Roman, Wenne, Agata, Drywa, Matthew, Kent, Kristil Kindem, Sundsaasen, Sigbjørn, Lien   +4 more
openaire   +2 more sources

Analyzing Cancer Samples with SNP Arrays

2011
Single nucleotide polymorphism (SNP) arrays are powerful tools to delineate genomic aberrations in cancer genomes. However, the analysis of these SNP array data of cancer samples is complicated by three phenomena: (a) aneuploidy: due to massive aberrations, the total DNA content of a cancer cell can differ significantly from its normal two copies; (b ...
Peter, Van Loo, Gro, Nilsen, Silje H, Nordgard, Hans Kristian Moen, Vollan, Anne-Lise, Børresen-Dale, Vessela N, Kristensen, Ole Christian, Lingjærde   +6 more
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A NEW GENOTYPE CALLING METHOD FOR AFFYMETRIX SNP ARRAYS

Journal of Bioinformatics and Computational Biology, 2011
Current genotype-calling methods such as Robust Linear Model with Mahalanobis Distance Classifier (RLMM) and Corrected Robust Linear Model with Maximum Likelihood Classification (CRLMM) provide accurate calling results for Affymetrix Single Nucleotide Polymorphisms (SNP) chips.
Bilin Fu, Jin Xu
openaire   +2 more sources

Contribution of SNP arrays in diagnosis of deletion 2p11.2–p12

Gene, 2012
Deletions of the short arm of chromosome 2 are exceedingly rare, having been reported in few patients. Furthermore most cases with deletion in 2p11.2-p12 have been studied using standard karyotype and so it is not possible to delineate the precise size of deletions.
Rocca, Maria Santa, Fabretto, Antonella, Faletra, Flavio, Carlet, Ombretta, Skabar, Aldo, Gasparini, Paolo, Pecile, Vanna   +6 more
openaire   +4 more sources

On Design of Oligonucleotide SNP Arrays and Methods for Genotype Calling

2008 International Conference on BioMedical Engineering and Informatics, 2008
The fast development of array technology has raised the density of oligonucleotide SNP arrays from 10 K and 50 K to 100 K and 500 K. However, methods for SNP genotyping have not been developed as fast. Most methods are based on sample-dependent multi-array training and may not be suitable for cross-laboratory studies and small sample studies, few use ...
Wenjiang J. Fu, Ming Li 0065, Lin Wan, Minghua Deng, Minping Qian   +4 more
openaire   +1 more source

A Method to Correct Systematic Bias in Affymetrix SNP Arrays

2008 International Conference on BioMedical Engineering and Informatics, 2008
Affymetrix SNP arrays are important tools and widely used for both genotyping and copy number estimation. We found previously that systematic bias exists in Affymetrix SNP arrays and leads to loss of accuracy in copy number estimations. In this paper, we showed that systematic bias within SNP arrays is multiplicative effect (or additive effects in the ...
Lin Wan, Wenjiang J. Fu, Minghua Deng, Minping Qian   +3 more
openaire   +2 more sources

Estimation of Missing Values in SNP Array

2014
DNA microarray usage in genetics is rapidly proliferating, generating huge amount of data. It is estimated that around 5-20% of measurements do not succeed, leading to missing values in the data destined for further analysis. Missing values in further microarray analysis lead to low reliability, therefore there is a need for effective and efficient ...
openaire   +1 more source

Use of SNP-Arrays for ChIP Assays: Computational Aspects

2009
The simultaneous genotyping of thousands of single nucleotide polymorphisms (SNPs) in a genome using SNP-Arrays is a very important tool that is revolutionizing genetics and molecular biology. We expanded the utility of this technique by using it following chromatin immunoprecipitation (ChIP) to assess the multiple genomic locations protected by a ...
Enrique M, Muro, Jennifer A, McCann, Michael A, Rudnicki, Miguel A, Andrade-Navarro   +3 more
openaire   +2 more sources

Exploring the cause of early miscarriage with SNP-array analysis and karyotyping

The Journal of Maternal-Fetal & Neonatal Medicine, 2017
The aim of this study is to explore the cause of miscarriage, providing risk assessment to guide the next pregnancy.Four hundred eighty-four products-of-conception (POC) samples were analyzed by single nucleotide polymorphism (SNP) array, and peripheral blood samples of couples were collected for karyotyping or fluorescence in situ hybridization (FISH)
Suzhen, Qu, Li, Wang, Aojie, Cai, Siying, Cui, Nan, Bai, Ning, Liu, Xiangdong, Kong   +6 more
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SNP arrays in Beckwith–Wiedemann syndrome: An improved diagnostic strategy

European Journal of Medical Genetics, 2013
Beckwith-Wiedemann syndrome is an overgrowth disorder with an increased risk of childhood tumors that results from a dysregulation of imprinted gene expression in the 11p15 region. Since epigenetic defects are the most frequent anomalies, first-line diagnostic methods involve methylation analysis.
Boris, Keren, Sandra, Chantot-Bastaraud, Frédéric, Brioude, Corinne, Mach, Eric, Fonteneau, Salah, Azzi, Christel, Depienne, Alexis, Brice, Irène, Netchine, Yves, Le Bouc, Jean-Pierre, Siffroi, Sylvie, Rossignol   +11 more
openaire   +2 more sources