Results 141 to 150 of about 434,626 (308)
Advanced Science, EarlyView.This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan +12 more
wiley +1 more source
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation
Advanced Science, EarlyView.Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang +7 more
wiley +1 more source
Rare Genetic Diseases with Founder Effect in Roma Children
Life(1) Background: The characteristics of rare diseases (RDs) vary considerably—not only between different disease types but also between individual patients with the same condition.
Simona Drobňaková +7 more
doaj +1 more source
SNP rs4420638; SNP rs11159647; SNP rs3826656 [PDF]
Science-Business eXchange, 2008 openaire +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Allele counts in TreeMix format and 4-SNP-block haplotypes
, 2015 Allele counts in TreeMix format and 4-SNP-block ...
Gregor Gorjanc (731703) +13 more
core +1 more source
Advanced Science, EarlyView.A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou +18 more
wiley +1 more source
Novel surfactant C variant c.325–47_374del without response to hydroxychloroquine treatment
Respiratory Medicine Case ReportsPathogenic variants of SP-C, which cause various lung diseases with varying ages of onset, are inherited in an autosomal dominant manner or appear de novo as new mutations. We present a case of fatal respiratory failure in a female infant.
Simona Drobnakova +6 more
doaj +1 more source
16. správa Faunistickej komisie Slovenskej ornitologickej spoločnosti/BirdLife Slovensko / The 16th report of the Rarities Committee of the Slovak Ornithological Society/BirdLife Slovakia [PDF]
Tichodroma, 2016 In 2015, the Rarities Committee of the Slovak Ornithological Society/BirdLife Slovakia reviewed 64 records, of which 57 were accepted in the category A, 1 in category C, one record in category D, three records in category E and one breeding record. Two
Richard KVETKO +1 more
doaj