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Empirical evaluation of analytic validity of polygenic scores. [PDF]

open access: yesGenome Med
Lin T   +16 more
europepmc   +1 more source

Generating SNP barcode to evaluate SNP–SNP interaction of disease by particle swarm optimization

Computational Biology and Chemistry, 2009
Genome-wide association analysis involved many single-nucleotide polymorphisms (SNPs) data is challenging mathematically and computationally. Hence, we propose the odds ratio-based discrete binary particle swarm optimization (OR-DBPSO) method that uses the OR as a new quantitative measure of disease risk among many SNP combinations with genotypes ...
Hsueh-Wei Chang   +2 more
exaly   +3 more sources

SNP‐SNP and SNP‐environment interactions of potentially functional HOTAIR SNPs modify the risk of hepatocellular carcinoma

Molecular Carcinogenesis, 2019
HOX transcript antisense intergenic RNA (HOTAIR) has been widely regarded as a functional lncRNA contributing to multiple cancers. However, few studies have examined the effect of single nucleotide polymorphisms (SNPs) in HOTAIR on the occurrence and development of hepatocellular carcinoma (HCC). In this study, three potentially functional HOTAIR SNPs (
Junguo Zhang   +12 more
openaire   +2 more sources

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