Results 291 to 300 of about 593,238 (360)

SNP to the rescue? [PDF]

open access: yesNature Reviews Drug Discovery, 2006
openaire   +2 more sources

Heritability and causality of QRS duration and chronic heart failure risk

open access: yesESC Heart Failure, EarlyView.
Methodological framework used to investigate the heritability using linkage disequilibrium score regression (LDSC) and causal relationship between QRS duration (exposure) and chronic heart failure (outcome) using Mendelian randomization. QRS data were sourced from GWAS and exome‐wide association studies (EWAS), and chronic heart failure GWAS data were ...
Zequn Zheng, Xinhan Li, Yongfei Song
wiley   +1 more source

SNPs by SPR [PDF]

open access: yesGenome Biology, 2001
openaire   +2 more sources

Circulating growth differentiation factor‐15 levels are associated with early echocardiographic signs of diastolic function impairment in the STANISLAS cohort: A 20‐year follow‐up study

open access: yesEuropean Journal of Heart Failure, EarlyView.
Summary of the study design and key findings. The (+) and (−) signs mean that the variable has a positive or a negative association with growth differentiation factor‐15 (GDF‐15) levels in the fully adjusted model (age, gender, current smoker, body mass index, total cholesterol, systolic blood pressure and N‐terminal pro‐B‐type natriuretic peptide ...
Luca Monzo   +11 more
wiley   +1 more source

From One Strand Dyed/Undyed Hair With/Without Root to Fast and Successful STR Profiling and Evaluation With Principle Component Analysis

open access: yesELECTROPHORESIS, EarlyView.
ABSTRACT Fallen/shed single hair shafts with/without roots can be encountered as evidence in crime scenes. Identification from hair exhibits serious difficulties, due to the low amount of DNA, PCR inhibitors, and the existence of DNA mostly in degraded forms. Exposure of hair to chemical oxidation, sunlight, etc.
Gulten Rayimoglu   +2 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons   +17 more
wiley   +1 more source

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