Results 141 to 150 of about 120,949 (314)

Harnessing molecular recognition for small molecule‐mediated, reversible photochemical control over mRNA translation

Angewandte Chemie International Edition, Accepted Article.
Chemical probes that control the function of complex RNA molecules offer unique opportunities to interrogate biological systems. In this study, we demonstrate that a small molecule ligand selectively recognizes and undergoes traceless, reversible photocrosslinking to PreQ1 RNA aptamers.
Shaifaly Parmar, Logan Tenney, Xiao Liang, John T. Routzahn, Christopher D. Sibley, John Schneekloth   +5 more
wiley   +1 more source

FastImpute: A Baseline for Open-source, Reference-Free Genotype Imputation Methods -- A Case Study in PRS313 [PDF]

arXiv
Genotype imputation enhances genetic data by predicting missing SNPs using reference haplotype information. Traditional methods leverage linkage disequilibrium (LD) to infer untyped SNP genotypes, relying on the similarity of LD structures between genotyped target sets and fully sequenced reference panels.
arxiv  

mendelFix: a Perl script for checking Mendelian errors in high density SNP data of trio designs [PDF]

arXiv, 2013
Here we present mendelFix, a Perl script for checking Mendelian errors in genome-wide SNP data of trio designs. The program takes 12-recoded PLINK PED and MAP files as input to calculate a series of summary statistics for Mendelian errors, sets missing offspring genotypes that present Mendelian inconsistencies, and implements a simplistic procedure to ...
arxiv  

L-RCA (ligation-rolling circle amplification): a general method for genotyping of single nucleotide polymorphisms (SNPs) [PDF]

, 2001
Xiaoquan Qi
openalex   +1 more source

Melting Curve Analysis of SNPs (McSNP ^® ): A Gel-Free and Inexpensive Approach for SNP Genotyping [PDF]

, 2001
Joshua M. Akey, Donna M. Sosnoski, Esteban J. Parra, S. Dios, K. Hiester, B. Su, Carolina Bonilla, Jin Li, Mark D. Shriver   +8 more
openalex   +1 more source

Genomic Evaluation of Recombination in Small Highly Inbred Beef Cattle Populations

Animal Research and One Health, EarlyView.
The study characterizes recombination in small beef cattle populations, revealing higher rates in CGC composites compared to inbred Line 1 Herefords. It identifies significant SNP associations linked to recombination across various autosomes, highlighting complex polygenic influences, with implications for genetic diversity and breeding strategies ...
E. Hay, A. S. Ling
wiley   +1 more source

Bean rust resistance in the Guatemalan climbing bean germplasm collection

Legume Science, Volume 4, Issue 4, December 2022., 2022
Abstract Common bean (Phaseolus vulgaris L.) is the main source of protein, fiber, and iron for Guatemala's poorest households. Bean rust (caused by Uromyces appendiculatus (Pers) Unger) can reduce seed yield up to 100%. There is limited information about U. appendiculatus virulence diversity in Guatemala, especially in the mid‐altitude highlands.
Luz de María A. Montejo Domínguez, Phillip E. McClean, James Steadman, Serena McCoy, Samuel Markell, Juan M. Osorno   +5 more
wiley   +1 more source

Honey Bee Breeding and Breed: Advancements, Challenges, and Prospects

Animal Research and One Health, EarlyView.
Our work clarifies concepts related to honey bee classification, reviews traditional and modern breeding techniques, explores advancements in molecular breeding, prospects gene‐editing tools, and advocates for integrated breeding strategies to ensure the long‐term sustainability and vitality of honey bee populations amid declining managed populations ...
Zheguang Lin, Lizhi Yang, Zhi Wang, Kang Wang, Qingsheng Niu, Ting Ji   +5 more
wiley   +1 more source

The compound heterozygous mutations of c.607G>a and c.657delC in the FAH gene are associated with renal damage with hereditary tyrosinemia type 1 (HT1)

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
This study demonstrated the novel compound heterozygous mutations (NM_000137: c.657delC (p.K220Rfs*12) and NM_000137: c.607G>A(p.A203T)) in FAH gene in a patient were responsible for HT1. We showed these FAH mutations were inherited in an autosomal recessive manner and resulted in abnormal FAH protein expression and dysfunction, leading to ...
Huan Chi, Chun Gan, Yaru Jiang, Dan Chen, Jiawen Qiu, Qing Yang, Yaxi Chen, Mo Wang, Haiping Yang, Wei Jiang, Qiu Li   +10 more
wiley   +1 more source

Shennong 1 Chicken 40K Liquid Chip: Advancing Genetic Research in Chinese Indigenous Chickens

Animal Research and One Health, EarlyView.
Based on comprehensive genomic data of Chinese indigenous chickens, we developed a specialized genotyping array for this population. Comparative analyses with published mainstream arrays and evaluations, including genetic assessment of diverse chicken types and gene mining analyses, demonstrated its superior applicability to Chinese indigenous chickens.
Chaoqun Gao, Chenxi Zhang, Kaiyuan Tian, Shucan Zhao, Yongle Xue, Sensen Yan, Chengpeng Xiao, Donghua Li, Guirong Sun, Ruili Han, Ruirui Jiang, Yadong Tian, Wenting Li, Kejun Wang, Xiangtao Kang   +14 more
wiley   +1 more source