Results 311 to 320 of about 219,632 (346)
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High-Throughput Methods for SNP Genotyping
2009Single nucleotide polymorphisms (SNPs) are ideal markers for identifying genes associated with complex diseases for two main reasons. Firstly, SNPs are densely located on the human genome at about one SNP per approximately 500-1,000 base pairs. Secondly, a large number of commercial platforms are available for semiautomated or fully automated SNP ...
Chunming, Ding, Shengnan, Jin
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2007
The identification of genes affecting complex traits (i.e., biological traits affected by several genetic and environmental factors) is a very difficult and challenging task (1, 2, 3). For many complex traits, the observable variation between individuals is quantitative; hence, loci affecting such traits are generally termed quantitative trait loci ...
Jun Wang +3 more
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The identification of genes affecting complex traits (i.e., biological traits affected by several genetic and environmental factors) is a very difficult and challenging task (1, 2, 3). For many complex traits, the observable variation between individuals is quantitative; hence, loci affecting such traits are generally termed quantitative trait loci ...
Jun Wang +3 more
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Allele-Specific PCR in SNP Genotyping
2009The increasing need for large-scale genotyping applications of single nucleotide polymorphisms (SNPs) in model and nonmodel organisms requires the development of low-cost technologies accessible to minimally equipped laboratories. The method presented here allows efficient discrimination of SNPs by allele-specific PCR in a single reaction with standard
Gaudet Muriel +3 more
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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005
In this review we describe the principles, protocols, and applications of two commercially available SNP genotyping platforms, the TaqMan SNP Genotyping Assays and the SNPlex Genotyping System. Combined, these two technologies meet the requirements of multiple SNP applications in genetics research and pharmacogenetics.
Francisco M, De la Vega +3 more
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In this review we describe the principles, protocols, and applications of two commercially available SNP genotyping platforms, the TaqMan SNP Genotyping Assays and the SNPlex Genotyping System. Combined, these two technologies meet the requirements of multiple SNP applications in genetics research and pharmacogenetics.
Francisco M, De la Vega +3 more
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Missing SNP Genotype Imputation
2011High-throughput single nucleotide polymorphism (SNP) genotyping technologies conveniently produce large SNP genotype datasets for genome-wide linkage and association studies. Various factors, from array design and hybridization, can give rise to a certain percentage of missing calls, and the problem becomes severe when the target organisms such as ...
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The TaqMan Method for SNP Genotyping
2009Single nucleotide polymorphisms (SNPs) are common DNA sequence variations that occur at single bases within the genome. SNPs have been instrumental in elucidating the genetic basis of common, complex diseases using genome-wide association studies, candidate gene case-control association studies, and genome-wide linkage analyses.
Gong-Qing, Shen +2 more
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[Approaches for SNP genotyping].
Yi chuan = Hereditas, 2009With the completion of the Human Genome Project (HGP), typing single nucleotide polymorphisms (SNP) has become one of the main tasks in the post-genome era. Consequently, a robust, flexible and cost-effective technique for SNP typing is essential to analyze a large number of SNPs.
Wei-Peng, Wang +2 more
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Machine Learning-Based Imputation of Missing SNP Genotypes in SNP Genotype Arrays
2013The missing value problem in SNP genotype data sets is introduced along with a short overview of two commonly used imputation algorithms, fastPHASE and KNNimpute, used to resolve the missing value problem for such data sets. A comparison of the two algorithms is provided with additional preliminary biological and mathematical background information for
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2010
Depending on the scope of the research project, categories of single-nucleotide polymorphism (SNP) genotyping experiments range from low to medium to high throughput, with each approach differing widely in cost, platform, and efficiency. Medium-throughput genotyping is generally appropriate for assaying up to 36 markers in 384 individuals and is ...
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Depending on the scope of the research project, categories of single-nucleotide polymorphism (SNP) genotyping experiments range from low to medium to high throughput, with each approach differing widely in cost, platform, and efficiency. Medium-throughput genotyping is generally appropriate for assaying up to 36 markers in 384 individuals and is ...
openaire +2 more sources