Results 61 to 70 of about 337,686 (261)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann +11 morewiley +1 more sourceThe Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits [PDF]
, 2012 Genome-wide association studies have identified hundreds of loci for type 2 diabetes, coronary artery disease and myocardial infarction, as well as for related traits such as body mass index, glucose and insulin levels, lipid levels, and blood pressure ...Kang, HM, Boehnke, M., Kathleen Stirrups, Ding, J., Abecasis, Gonçalo R., Samani, NJ, Winckler Wendy, Sanna, Serena, Teslovich, T.M., McCarthy, Mark I, Teslovich, Tanya M., Pfeufer, Arne, Kathiresan, S., Morris Andrew P., Potter, S, Wheeler, E., Boehnke, M, Ruth J. F. Loos, Sanna, S, Jackson, Anne U., Melissa Parkin (145722), Joel N Hirschhorn, Randall, Joshua C, Sanna, S., Palmer, C.D., Hirschhorn, Joel, Heid Iris M., Wendy Winckler (145732), Chines Peter S., S. Potter (6187), Palmer, CD, Winckler, Wendy, Barroso, Inês, S. Sanna (7609256), Erdmann Jeanette, Loos, Ruth J F, N. Robertson (61307), D. Altshuler (7606010), Randall, J.C., Frayling, Timothy M., Fuchsberger Christian, Heid, I.M., C. D. Palmer (7626644), Altshuler, D., E. Wheeler (4607599), Speliotes, E.K., N. W. Rayner (7626794), Newton-Cheh Christopher, Joshua C. Randall (145712), Munroe, PB, Kilpeläinen, T.O., Cecilia M Lindgren, Stirrups, K., Voight, Benjamin F., Mulas Antonella, Potter, Simon, Parkin, M, Chines, P.S., Serena Sanna (145737), Cameron D Palmer, Gonçalo R Abecasis, Mark I. Mccarthy, Francesco Cucca (145742), J. N. Hirschhorn (7609139), Pfeufer Arne, Johnson, T, Michael Boehnke (145750), Sidore, Carlo, Johnson, T., T. M. Teslovich (7683197), Eleanor Wheeler, R. Saxena (7608878), I. Prokopenko (7608875), Antonella Mulas, Maguire, J., Tuomas O. Kilpeläinen (145704), Peter S Chines, T. O. Kilpeläinen (7683194), McCarthy, MI, C. M. Lindgren (7611374), N. William Rayner (21703), Benjamin F. Voight, Voight Benjamin F., McCarthy Mark I., Li, Y.M., Peter S. Chines, Saxena, R, A. Pfeufer (7670843), Morris, Andrew, Antonella Mulas (145739), Hirschhorn Joel N., Gonçalo R. Abecasis (36598), Prokopenko, Inga, Morris, AP, Teslovich, Tanya M, I. M. Heid (7611266), Schunkert, H, Carlo Sidore (145691), Kilpeläinen, TO, P. S. Chines (7626599), Robertson, N, Frayling Timothy M., Deloukas Panos, Cucca, F., Abecasis, G.R., N. J. Samani (7591811), Noël P. Burtt, Kang, H.M., Schunkert, H., Morris, Andrew P, Chines, Peter S, B. F. Voight (7605833), P. B. Munroe (7602386), Neil Robertson, Erdmann, Jeanette, Maguire, Jared, Chines, PS, Loos, Ruth J. F., Inga Prokopenko (43252), Li, YM, Parkin Melissa, Erdmann, J., McCarthy, Mark, Loos, RJF, Potter Simon, Munroe, Patricia B., Richa Saxena (28290), Yanming Li (145698), Andrew P Morris, Jackson, A.U., Robertson, N., Et Al, Oskari Kilpeläinen, Tuomas, Noël P. Burtt (145695), E. K. Speliotes (7611380), Nagaraja, Ramaiah, Iris M Heid, Winckler, W, Sanna Serena, Rayner, N.W., Deloukas, P., Fuchsberger, Christian, Erdmann, J, S. Kathiresan (7606013), Toby Johnson, Joel N. Hirschhorn, Iris M. Heid, Neil Robertson (25148), Tanya M. Teslovich (145718), F. Cucca (7683212), Frayling, TM, W. Winckler (7683209), Toby Johnson (43283), Jackson Anne U., Hyun Min Kang, McCarthy, M.I., Ruth J F Loos, Morris, Andrew P., Munroe, P.B., J. Ding (2126038), Parkin, M., Boehnke Michael, N William Rayner, M. Boehnke (7605344), David Altshuler, Burtt, Noël P., Deloukas, Panos, Jackson, Anne U, Burtt, NP, Melissa Parkin, Prokopenko Inga, Nicole Soranzo Elizabeth K. Speliotes, Newton-Cheh, C, A. Mulas (7626920), Abecasis, GR, Jared Maguire (145720), Iris M. Heid (87553), Speliotes, EK, Carlo Sidore, Benjamin F. Voight (145685), Kilpelaeinen, TO, Cucca, Francesco, T. Johnson (7602368), Mark I McCarthy, Li Yanming, Robertson Neil, Hirschhorn, Joel N, Ding Jun, Panos Deloukas (21564), David Altshuler (27754), Maguire, J, Sidore, C., Soranzo Nicole, Ding, J, Yanming Li, Fuchsberger, C., Andrew P. Morris, Kang, Hyun Min, Burtt, Noël P, Wheeler, Eleanor, Joel N. Hirschhorn (131545), Kilpeläinen, Tuomas O., Anne U Jackson, Altshuler, David, Nagaraja, R, Palmer Cameron D., Sidore, C, Benjamin F Voight, Panos Deloukas, Peter S. Chines (145692), Inês Barroso (2144), H. M. Kang (7626701), Timothy M. Frayling, Munroe, Patricia B, Heid, Iris M., Lindgren, Cecilia M., Deloukas, P, Jackson, AU, Citable Link, Jeanette Erdmann (44256), Citation Voight, Wendy Winckler, Nagaraja, R., Serena Sanna, Y. Li (696089), Speliotes, Elizabeth K, Gonçalo R. Abecasis, Samani, Nilesh J., Robertson, Neil, Ruth J. F. Loos (110224), Newton Cheh, C, Lindgren, Cecilia, Wheeler, E, Voight, Benjamin F, Arne Pfeufer, Stirrups Kathleen, G. R. Abecasis (7602524), Newton-Cheh, Christopher, Francesco Cucca, Soranzo, N, Nilesh J. Samani (60118), Speliotes, Elizabeth K., Jeanette Erdmann, Schunkert Heribert, Simon Potter (145724), Altshuler David, Hyun Min Kang (145687), Heid, IM, Fuchsberger, C, Mark I. McCarthy (145748), Tuomas O. Kilpeläinen, Newton-Cheh, C., A. U. Jackson (7609325), Voight, BF, R. J. Loos (7608845), Inga Prokopenko, Lindgren, Cecilia M, Joshua C Randall, Chines, Peter S., Ramaiah Nagaraja, Burtt, N.P., Jun Ding (80820), Barroso, I., Timothy M Frayling, Andrew P. Morris (145709), Pfeufer, A., Heid, Iris M, Ding, Jun, Rayner N. William, Samani, N.J., Kathiresan, S, Speliotes Elizabeth K., Altshuler, D, I. Barroso (7609532), Palmer, Cameron D, Patricia B Munroe, Ramaiah Nagaraja (2394), Pfeufer, A, Soranzo, N., Boehnke, Michael, Burtt Noël P., Arne Pfeufer (76634), Eleanor Wheeler (28941), Sekar Kathiresan (60585), Parkin, Melissa, Sidore Carlo, Cecilia M. Lindgren (145706), Maguire Jared, C. Newton-Cheh (7602563), Patricia B. Munroe (145744), H. Schunkert (7603670), Rayner, N William, Randall, JC, Saxena Richa, McCarthy, Mark I., Saxena, Richa, Frayling, Timothy M, Patricia B. Munroe, Li, Y, Abecasis, Gonçalo R, Winckler, W., Nilesh J. Samani, Heribert Schunkert (44257), Kang Hyun Min, Prokopenko, I, Li, Yanming, N. Soranzo (7608857), Christian Fuchsberger (76512), Timothy M. Frayling (145700), Saxena, R., Samani Nilesh J., Kathleen Stirrups (145729), Teslovich, TM, Nicole Soranzo (12361), Sekar Kathiresan, Samani, Nilesh J, J. Maguire (7683200), Hirschhorn, J.N., Tanya M Teslovich, Inês Barroso, Stirrups, K, Palmer, Cameron Douglas, Palmer, Cameron D., Prokopenko, I., Soranzo, Nicole, C. Sidore (7683188), Rayner, N. William, Johnson, Toby, Voight, B.F., N. William Rayner, Randall, Joshua C., Jun Ding, Lindgren Cecilia M., Elizabeth K Speliotes, Richa Saxena, Cameron D. Palmer, Christopher Newton-Cheh, Cecilia M. Lindgren, Elizabeth K. Speliotes (145716), Nagaraja Ramaiah, Nicole Soranzo, Johnson Toby, Loos, RJ, Cucca, F, Loos Ruth J. F., Mulas, Antonella, Abecasis Gonçalo R., Anne U. Jackson (145702), Mulas, A, Teslovich Tanya M., Randall Joshua C., Rayner, NW, Heribert Schunkert, Barroso, I, Cameron D. Palmer (131509), Stirrups, Kathleen, Hirschhorn, Joel N., P. Deloukas (7603691), Barroso Inês, Gibson, Greg, Lindgren, C.M., Michael Boehnke, Schunkert, Heribert, Lindgren, CM, Loos, R.J.F., Noël P Burtt, Munroe Patricia B., C. Fuchsberger (7683191), T. M. Frayling (7608959), J. C. Randall (7611377), Kathiresan, Sekar, Frayling, T.M., Jared Maguire, M. Parkin (7683203), Christopher Newton-Cheh (79953), Tuomas O Kilpeläinen, J. Erdmann (7603664), Wheeler Eleanor, Morris, A.P., Potter, S., Kathiresan Sekar, Mulas, A., Christian Fuchsberger, Joshua C. R, Cucca Francesco, K. Stirrups (7683206), M. I. McCarthy (7609121), Simon Potter, Anne U. Jackson, Hirschhorn, JN, A. P. Morris (7611419), N. P. Burtt (7605932), Benjamin F, Nilesh J Samani, R. Nagaraja (7612157), Kilpeläinen Tuomas O. +395 morecore +1 more sourceSpatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours +11 morewiley +1 more sourceDevelopment of a temperature-switch PCR-based SNP typing method for Mycobacterium ulcerans [PDF]
, 2012 Mycobacterium ulcerans (M. ulcerans), the causative agent of the devastating skin disease Buruli ulcer (BU), is characterized by an extremely low level of genetic diversity.Danso Emelia, Röltgen, K., Gerd Pluschke, Pluschke Gerd, Yeboah-Manu, D., Katharina Röltgen, Dorothy Yeboah-Manu (120059), Gerd Pluschke (7855), Emelia Danso, Katharina Röltgen (120045), Danso, E., Pluschke, G., Kobina Assan-Ampah, Emelia Danso (120054), Dorothy Yeboah-Manu, Kobina Assan-Ampah (120049), Yeboah-Manu Dorothy, Assan-Ampah Kobina, Assan-Ampah, K., Röltgen Katharina +19 morecore +1 more sourceTranslating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD) Sejung Lee, Junghyeok Lim, Jinhyuk Bhinwiley +1 more sourceMolecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith +12 morewiley +1 more sourceA single-nucleotide-polymorphism real-time PCR assay for genotyping of mycobacterium tuberculosis complex in peri-urban Kampala [PDF]
, 2015 Accurate and high-throughput genotyping of Mycobacterium tuberculosis complex (MTBC) may be important for understanding the epidemiology and pathogenesis of tuberculosis (TB).Eddie M. Wampande, Kathleen Eisenach, Mary Nsereko, Stavroula K. Hatzios, Wampande, Eddie M., Hatzios, Stavroula K., Mayanja, Harriet K., Mupere, Ezekiel, Gagneux, Sebastien, Eisenach, Kathleen, Joloba, Moses L., Moses L. Joloba, Achan, Beatrice, Ezekiel Mupere, Nsereko, Mary, Sebastien Gagneux, Harriet K. Mayanja, null null, Boom, W Henry, Boom, W. Henry, W Henry Boom, Tuberculosis Research Unit,, Beatrice Achan +22 morecore +2 more sourcesEvolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna +6 morewiley +1 more source
