Results 121 to 130 of about 384,456 (306)
Metodología para la construcción de redes de SNPs relacionados con enfermedades complejas [PDF]
, 2011 El estudio de asociación entre enfermedades complejas y genotipos con base en marcadores genéticos o SNPs (Polimorfismos de Nucleótidos Simples) por sus siglas en ingles, ha tomado importancia en los ´ultimos años.
Castillo Abril, Iván Dario
core
Advanced Science, EarlyView.Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin +12 more
wiley +1 more source
Consequences of pQTL SNPs. [PDF]
, 2016 We examined the most significant SNP for each biomarker (top pQTL) and all 590 significant pQTL SNPs (all pQTLs), compared to all 664,913 SNPs (all SNPs) used for testing with the Ensemble Variant Effect Predictor (release 78).
Katerina Kechris (436022) +44 more
core +1 more source
Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants
Advanced Science, EarlyView.A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei +8 more
wiley +1 more source
Detecting high-order interactions of single nucleotide polymorphisms using genetic programming [PDF]
Motivation: Not individual single nucleotide polymorphisms (SNPs), but high-order interactions of SNPs are assumed to be responsible for complex diseases such as cancer. Therefore, one of the major goals of genetic association studies concerned with such
Schwender, Holger +4 more
core
Advanced Science, EarlyView.ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun +19 more
wiley +1 more source
NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice
Advanced Science, EarlyView.In rice, NLSS3 binds and shields SHM1 from autophagic degradation to maintain serine homeostasis. The A132P mutation in nlss3 disrupts this, triggering SHM1 loss, metabolic dysfunction, K+ imbalance, and impaired ROS scavenging, which collectively drive narrow leaves and salt sensitivity.
Xiong Liu +15 more
wiley +1 more source
Iatreia, 2010 La sepsis se define como un síndrome de respuesta sistémica en presencia, confirmada o sospechada de infección. Se manifiesta con uno o varios marcadores de enfermedad general, inflamación, anormalidad hemodinámica, disfunción orgánica o falla de ...
Carolina Montoya Ruiz +3 more
doaj
Mutation screening of γ-crystallin gene in congenital cataract patients from North India
Indian Journal of OphthalmologyPurpose: The present study screened eight families (comprising 25 affected and unaffected individuals, along with ten unrelated controls) to identify known and potentially novel mutations in the human γ-crystallin (CRYG) genes using Sanger bidirectional ...
Aal E Fatima +2 more
doaj +1 more source
PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes
Advanced Science, EarlyView.A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li +10 more
wiley +1 more source