Results 201 to 210 of about 524,252 (269)

Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar, Natasha Monte da Silva, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐dos‐Santos, Sandro José de Souza, Ândrea Ribeiro‐dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista dos Santos, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +9 more
wiley   +1 more source

Exploring Genomic Variability in the Mediterranean Buffalo Breed: A Step Towards Custom SNP Array. [PDF]

Animals (Basel)
Arcuri C, Gabbianelli F, Bencivenga F, Porcai G, Pietrucci D, Picarone L, Vignali G, Toscano E, Di Maggio F, Sepe L, Nunziato M, Manunza A, Lazzari B, Cozzi P, Rizzo F, Weisz A, Smal M, Biffani S, Castiglioni B, Paolella G, Salvatore F, Rullo A, Rubinacci S, Cosenza G, Carpio MG, Cimmino R, Di Vuolo G, Iannuzzi L, Milanesi M, Chillemi G.   +29 more
europepmc   +1 more source

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, EarlyView.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source

Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans. [PDF]

PLoS Genet
Comerford M, Vespasiani DM, Shukla N, Cook LE, Yermakovich D, Dannemann M, Leavesley M, Kinipi C, Ricaut FX, Brucato N, Cox MP, Gallego Romero I.   +11 more
europepmc   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Inference of admixture in dogs from whole genome sequences. [PDF]

GigaByte
Kislik G, Moore G, Rubbi L, Supara VN, Chen G, Pellegrini M.   +5 more
europepmc   +1 more source

Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21 [PDF]

, 2018
Rubin, Joshua B.
core   +1 more source

Myopia Development and Control: An Integrative Review of Genetic, Optical, and Environmental Mechanisms With Implications for Personalized Intervention

Eye &ENT Research, EarlyView.
ABSTRACT Myopia is a rapidly growing global health challenge, affecting 1.9 billion people and projected to reach 4.9 billion by 2050, with high myopia and its sight‐threatening complications such as maculopathy, retinal detachment, and glaucoma increasing disproportionately.
Victor Opoku‐Yamoah, Sahar Khakneshin, Ebenezer Afrifa‐Yamoah   +2 more
wiley   +1 more source

Genetic Variations in the M6A Modification Pathway as Potential Predictors of Imatinib Secondary Resistance in Gastrointestinal Stromal Tumors. [PDF]

J Clin Med
Zhou B, Chen Z, Zhang G, Guan S, Zhuang W, Huang M, Qiu H, Wang X.   +7 more
europepmc   +1 more source