Results 111 to 120 of about 10,825 (231)

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3333-3353, October 2026.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Agomelatine as augmentation therapy with second‐generation antipsychotics for negative symptoms of schizophrenia: An open‐label randomised clinical trial and electroencephalogram‐derived model for treatment response prediction

General Psychiatry, Volume 39, Issue 5, October 2026.
ABSTRACT Background Negative symptoms are a core diagnostic domain of schizophrenia that affect functional outcomes and remain difficult to treat. Agomelatine, a novel antidepressant with melatonin receptor agonism and serotonin 2C receptor antagonism, may have therapeutic potential.
Wanyan Zhou, Fei Liang, Nizhe Chen, Yao Zhang, Xiaoxiao Wang, Xin Li, Daofeng Lu, Fang Guo, Yuan Yao, Jiayu Zhu, Chengjia Shen, Chongze Wang, Peiyun Zhang, Lilan Zhao, Ying Wang, Jinyu Han, Wei Li, Haisu Wu, Peijuan Wang, Qi Yan, Ping Zhang, Qinyu Lv, Zhenghui Yi   +22 more
wiley   +1 more source

Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

International Journal of Gynecology &Obstetrics, Volume 175, Issue 1, Page 26-47, October 2026.
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay   +8 more
wiley   +1 more source

Evaluating the Impact on Adult Caregivers of Family‐Based Treatment for Childhood Obesity

Obesity Science &Practice, Volume 12, Issue 5, October 2026.
ABSTRACT Background Weight management in children involves family lifestyle changes and relies on caregivers of children to implement these changes at home. Little is known about the effects of family‐based lifestyle intervention programs for children on caregivers themselves when not specifically targeted by the intervention.
Paola Luca, Amy Bobyn, Grace P. S. Kwong, Alberto Nettel‐Aguirre, Ronald Sigal, Emma O. Billington, Raylene A. Reimer, Josephine Ho   +7 more
wiley   +1 more source

Exploring vortioxetine combination with intranasal esketamine: A feasible alternative to SSRI/SNRI? - Insights from the REAL-ESK study

Background: Treatment-Resistant Depression (TRD) affects almost 30 % of patients with Major Depressive Disorder (MDD). Esketamine Nasal Spray (ESK-NS) has recently been approved for TRD in combination with a Serotonin Specific Reuptake Inhibitor/SSRI or ...
Di Lorenzo G., Barlati S., Miuli A., Sensi S. L., Martinotti G., Cocco A., Cavallotto C., De Filippis S., d'Andrea G., Dell'Osso B. M., Marrangone C., Andriola I., Pettorruso M., Martiadis V., Vita A.   +14 more
core   +2 more sources

Trends and Gender Disparities in Medical Narcotics Utilization in South Korea: A Nationwide Population‐Based Study, 2019–2023

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 10, October 2026.
ABSTRACT Background In South Korea, a substantial volume of prescription psychotropics is dispensed outside the national health insurance reimbursement system, creating a pharmacovigilance blind spot. We investigated nationwide utilization patterns of medical narcotics to identify potential safety signals using the Narcotics Information Management ...
Jin‐Hwan Kim, Jonghun Kim, Saerom Kim
wiley   +1 more source

The Role of the Antidepressants in Managing Chemotherapy‐Induced Neuropathic Pain: A Systematic Review

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From symptom relief to multimodal care: duloxetine and amitriptyline may reduce established CIPN‐related pain and provide a therapeutic foundation for future combination strategies. ABSTRACT Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and debilitating complication of cancer treatment, characterized by neuropathic pain, sensory ...
Rosamaria Caminiti, Valeria Mazza, Saverio Nucera, Francesca Oppedisano, Lucia Carmela Passacatini, Jessica Maiuolo, Valentina Malafoglia, Alessandro Giorgio, Andrea Soluri, Claudia Pileggi, Carlo Tomino, Vincenzo Mollace, Sara Ilari, Carolina Muscoli   +13 more
wiley   +1 more source

Psychopathological symptoms in fibromyalgia and their associations with resistance to pharmacotherapy with SNRI

Psychiatria Polska
Cel pracyWstęp: Fibromialgia (FM) często współwystępuje z zaburzeniami psychicznymi. Ponadto, kilka badan wskazuje, że zaburzenia psychiczne mogą być związane z nasileniem i wpływem FM. Celem naszej pracy było po pierwsze: ocenić różne wymiary objawów psychopatologicznych wśród pacjentów z FM i po drugie: zbadać zależności pomiędzy psychopatologią a ...
Anna Julia Krupa, Adrian Andrzej Chrobak, Zbigniew Sołtys, Mariusz Korkosz, Jaroslaw Nowakowski, Dominika Dudek, Marcin Siwek   +6 more
openaire   +2 more sources

Medicine Use Preceding Fatal Poisonings Among Individuals With Bipolar Disorder

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Pharmacotherapy may reduce overall suicide risk in bipolar disorder, but prescribed medicines can also be causative agents in suicidal and accidental poisonings. This nationwide, nested case–control study utilized data from several national registers in Finland in 1996–2018.
Janina Salmelainen, Miia Tiihonen, Heidi Taipale, Johannes Lieslehto, Antti Tanskanen, Jari Tiihonen, Aleksi Hamina   +6 more
wiley   +1 more source

Tillägg av mirtazapin och kognitiv beteendeterapi (KBT) vid otillräcklig effekt av SSRI eller SNRI vid depression : Mirtazapin-och KBT tillägg vid otillräcklig effekt av SSRI eller SNRI vid depression

En av de vanligaste folksjukdomarna är depression med symtom som ångest, sömnsvårigheter, samt minskad aptit. År 2019 hade cirka 280 miljoner individer upplevt depression, där det var vanligare bland kvinnor än män. Depression kan drabba individer i alla
Hashim Bashir, Ziad
core   +2 more sources