Results 51 to 60 of about 8,567 (186)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Brain Health in Neuroradiology

Clinical and Translational Neuroscience
Neuroradiology, as a modern branch of the neurosciences and radiological sciences, has an impact on global health, particularly on brain health.
Karl-Olof Lövblad, Isabel Wanke, Daniele Botta, Felix T. Kurz, Roland Wiest, Daniel Rüfenacht, Luca Remonda   +6 more
doaj   +1 more source

Galactorrhea with antidepressants: A case series

Indian Journal of Psychiatry, 2018
Galactorrhoea is a rare but distressing, and often embarrassing adverse effects of selective serotonin reuptake inhibitors (SSRIs) treatment. Here we report three cases that developed galactorrhoea with combination of SSRIs or combination of SSRI and ...
Navratan Suthar, Vrinda Pareek, Naresh Nebhinani, Deep Kunwar Suman   +3 more
doaj   +1 more source

The role of peripheral serotonin in SARS‐CoV‐2 infectivity, COVID‐19 treatment and long COVID

Immunology &Cell Biology, EarlyView.
In this article, we discuss how SARS‐CoV‐2 infects the gastrointestinal tract, that enterochromaffin cells, the source of circulating serotonin, uniquely express viral entry receptors. We examine how this infection disrupts gut‐derived serotonin, contributing to gastrointestinal symptoms and disease severity, and link elevated plasma serotonin to COVID‐
Daniel W Thorpe, Lauren A Jones, Alyce M Martin, Rosemary A Coleman, Caitlin Allman, Rochelle A Peterson, Damien J Keating   +6 more
wiley   +1 more source

[Discontinuation of SSRIs and SNRIs].

Nederlands tijdschrift voor geneeskunde, 2020
Interruption or abrupt discontinuation of the use of antidepressants may lead to withdrawal symptoms. These are most common with selective serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline reuptake inhibitors (SNRIs).There is insufficient scientific evidence about the prevalence of antidepressant withdrawal symptoms and how to optimally
Ruhe, H.G., Horikx, A., Avendonk, M.J.P van, Groeneweg, B.F., Mulder, H., Woutersen-Koch, H.   +5 more
openaire   +3 more sources

Pregabalin efficacy in painful diabetic peripheral neuropathy: A focused analysis of optimal dosing and the relationship of baseline glycemic control

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Introduction Diabetic neuropathy, the most common long‐term complication of diabetes, frequently presents as painful diabetic peripheral neuropathy (pDPN), significantly impairing patients' quality of life. Pregabalin is an established treatment for pDPN, but optimal dosing and the influence of glycemic control on efficacy remain uncertain ...
Ashish Bajaj, Gordon Sloan, Chris Walker, Egbert Biesheuvel, Sagar Suresh Kumbhar, Gavin Lyndon, Solomon Tesfaye   +6 more
wiley   +1 more source

Migraine and Restless Legs Syndrome: A Meta‐Analysis

Journal of Sleep Research, EarlyView.
ABSTRACT Restless legs syndrome is a sensorimotor disorder of sleep/wake regulation that frequently coexists with migraine, affecting patients' quality of life. This study aimed to estimate the prevalence of restless legs syndrome in individuals with migraine and to explore the associated clinical, demographic and behavioural aspects.
Florindo d'Onofrio, Maria Cropano, Giada Panzino, Mariachiara Gaita, Giulio Cicarelli, Piero Barbanti, Gerardo Casucci, Simona Raimo, Antonio Costanzo   +8 more
wiley   +1 more source

Functional and structural connectivity of thalamic subnuclei in major depressive disorder at 7 Tesla

Psychiatry and Clinical Neurosciences, EarlyView.
Aims Major depressive disorder (MDD) is widely considered to be a mood disorder characterized by altered connectivity. The thalamus plays an important role in MDD by connecting large areas of the brain. Here, we explored thalamic connectivity in MDD at the subnuclear level using ultra‐high‐field MRI.
Weijian Liu, Shu Liu, Jurjen Heij, Laurens A. van de Mortel, Luka Liebrand, Matthan Caan, Wietske van der Zwaag, Dick J. Veltman, Lin Lu, Moji Aghajani, Guido van Wingen   +10 more
wiley   +1 more source

Recommended Corrective Security Measures to Address the Weaknesses Identified Within the Shapash Nuclear Research Institute

International Journal of Nuclear Security, 2018
The Shapash Nuclear Research Institute (SNRI) data book was issued by the International Atomic Energy Agency (IAEA) in 2013. The hypothetical facility data book describes the hypothetical site, which is divided into two areas: the low-security area ...
Khadija Moussaid, Oum Keltoum Hakam
doaj   +1 more source

Psychotropic medication and the fetal brain

The Journal of Physiology, EarlyView.
Abstract figure legend Brain region changes linked to in‐utero psychotropic exposure. Abstract Medications known to cross the blood–brain barrier (psychotropic medications) are commonly prescribed to women during pregnancy, often for the management of mental illness.
Oliver Gale‐Grant, Tomoki Arichi
wiley   +1 more source