Results 101 to 110 of about 61,991 (349)

Gender differences in the impact of population-level alcohol policy interventions: evidence synthesis of systematic reviews [PDF]

, 2016
Background: Consistent review-level evidence supports the effectiveness of population-level alcohol policies in reducing alcohol-related harms. Such policies interact with well-established social, cultural and biological differences in how men and women ...
Amos, Annandale, Babor, Bambra, Beaglehole, Bergen, Bolier, Bonell, Booth, Borsari, Brennan, Brown, Bryden, Campbell, Cashman, Champion, D'Onise, Daly, Daykin, Derzon, Ditter, Doyal, Elder, Elder, Elder, Elder, Emslie, Emslie, Emslie, Emslie, Erke, Erol, European Association of Science Editors, Fletcher, Foxcroft, Foxcroft, Foxcroft, Goss, Greaves, Hahn, Hahn, Hale, Himmelweit, Holmes, Holmes, Holmila, Hughes, Jackson, Janer, Janssen, Jones, Kazemi, Ker, Keyes, Killoran, Kuntsche, Lachenmeier, Langford, Lemstra, Leon, Loveland-cherry, Lyons, Martens, Martineau, McCartney, Middleton, Moreira, Nolen-Hoeksema, Ostlin, Ostlin, Payne, Petrie, Phillips, Plant, Pollack, Pollack, Popova, Popova, Probst, Rammohan, Reavley, Rodriguez, Runnels, Russell, Schmidt, Scholes-Balog, Scott-Sheldon, Sen, Sen, Shipton, Shults, Smith, Snyder, Stead, Teesson, True, Visser, Visser, Wagenaar, Wagenaar, Webb, Welch, Wilsnack, Wilsnack, Wilsnack, Wilsnack, Wood   +106 more
core   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Frugality [PDF]

Frugality is a little studied virtue, but one that is important to the lives of individuals and families, communities and broader societies. In this article we consider what we mean by frugality and discuss its role in the decision-making process, within
Argandoña, Antonio
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Quelle gouvernance pour un numérique sobre ?

Sociologies
Faced with the need to reduce the footprint of human activities, incentives to practise sobriety are multiplying, particularly in the digital sector.
Valérie Deruelle, Jean-Luc Metzger
doaj   +1 more source

An Alcohol Mindset in a Drug-Crazed World: A Review of Birchfield v. North Dakota [PDF]

, 2017
Birchfield v. North Dakota involved the ability of legislatures to criminalize a driver’s refusal to submit to a chemical test after a law enforcement officer arrested the individual for driving under the influence of alcohol or drugs.
Beeny, Devon
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

PUBLIC ORGANIZATIONS OF RUSSIA IN FIGHT AGAINST ALCOHOLISM IN THE SECOND HALF OF XIX - EARLY XX CENTURY: SOCIAL PRACTICES

Гуманитарные и юридические исследования, 2021
The article studies the movement against drinking in Russia in the second half of the 19th - early 20th century, the methods to tackle alcoholism of the population. The reasons that led to alcohol consumption in the working, peasant, soldier environment,
E. Luybyshkina
doaj  

Brief Amicus Curiae of the Honorable Margaret W. Hassan Governor of the State of New Hampshire in Support of the Plaintiffs/Cross-Appellants [PDF]

, 2014
SUMMARY OF ARGUMENT The Governor confines her argument in this amicus brief to whether the superior court correctly concluded that the education tax credit program enacted under RSA § 77-G violates Article 83 insofar as it permits organizations ...
Greabe, John M., Hodder, Lucy C.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source