Results 141 to 150 of about 798,697 (287)

[Review of] Alain LeRoy Locke (Jeffrey C. Stewart, ed.). Race Contacts and Interracial Relations: Lectures on the Theory and Practice of Race [PDF]

open access: yes, 1993
Scholars of the history of race and race relations social science should be deeply indebted to Jeffrey C. Stewart for uncovering and meticulously reconstructing these extant lectures by the philosopher better known for his later contributions to the ...
Williams, Vernon, Jr
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Communicating Resilience: A Discursive Leadership Perspective [PDF]

open access: yes, 2013
In this essay we challenge whether current conceptions of optimism, hope, and resilience are complete enough to account for the complexity and nuance of developing and maintaining these in practice.
Fyke, Jeremy P., Torres, David H
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

HIGHER EDUCATION AND SOCIETY: RUSSIA AND OTHER COUNTRIES

open access: yesВысшее образование в России, 2016
Higher education is an institute of excellent importance for society and its development deeply depends on public support. It’s impossible to score a success with poor finance, bad infrastructure and without legal protection.
Anatoliy I. Rakitov, Alina E. Anisimova
doaj  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare. [PDF]

open access: yesPLoS One, 2016
Davies GF   +41 more
europepmc   +1 more source

The Social Construction of Successful Market Reforms [PDF]

open access: yes
The transition from socialism to capitalism has spawned a large literature on comparative policy reforms. While many sociologists using qualitative data have concluded that neo-liberal reforms led to negative outcomes, a large body of cross-national ...
David Stuckler   +2 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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