Results 41 to 50 of about 624,383 (304)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Action and Ethics. A Historical Perspective on the Late Frankfurt School (Apel, Habermas, Wellmer) [PDF]
, 2016 I shall delineate what I see as the strength and relevance of transcendental-pragmatics within the intellectual setting in the post-war period. I shall indicate how the discussions within transcendental-pragmatics have revealed inherent challenges, while
Skirbekk, Gunnar
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Brain study confirms gender stereotypes: How science communication can fuel modern sexism. [PDF]
, 2015 The way much research on sexual differentiation is conducted and communicated has come under intense criticism from scholars in both the natural and social sciences.
O'Connor, Cliodhna
core
The explanationist argument for moral realism [PDF]
, 2011 In this paper I argue that the explanationist argument in favour of moral realism fails. According to this argument, the ability of putative moral properties to feature in good explanations provides strong evidence for, or entails, the metaphysical ...
Neil Sinclair, Nottingham Ng Rd
core +3 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
HTS Teologiese Studies/Theological Studies, 1998 What does 'canon' mean at present? The notion of canon has become quite complicated. In textual criticism it is no longer possible to identiy the canon with only one form of the textual tradition.
P. M. Venter
doaj +1 more source
(WP 2012-01) Samuels on Methodological Pluralism in Economics [PDF]
, 2012 Warren Samuels was an influential proponent of methodological pluralism in economics. This short paper discusses his understanding of methodological pluralism, and argues that it is based on three distinct components: (1) his critique of the idea that ...
Davis, John
core +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
An Introduction to Content Analysis of Critical Papers Related to Iran's Political-Social Issues [PDF]
پژوهشنامۀ انتقادی متون و برنامههای علوم انسانی, 2017 This article analyzed critical papers related to the political-social issues of Iran. The purpose of the research was to identify the observance level of the fundamentals of criticism and scientific evaluation in critical papers.
Qolamreza Mohammadi Mehr +1 more
doaj