Results 41 to 50 of about 623,753 (303)

Intractable policy failure: the case of bovine TB and badgers [PDF]

, 2009
The failure to eliminate bovine TB from the English and Welsh cattle herd represents a long-term intractable policy failure. Cattle-to-cattle transmission of the disease has been underemphasised in the debate compared with transmission from badgers ...
Assembly Welsh, Dunnet G., Edelman M., House of Commons, House of Commons, Independent Scientific Group, King D., Ministry of Agriculture, Fisheries and Food, NA PRO: HO 285/40b, NA PRO: MAF 459/12, NA PRO: MAF 459/16, NA PRO: MAF 459/37, NA PRO: MAF 459/66, Schön D. A., Wilkinson K., Woods A., Wyn Grant, Zuckerman Lord   +17 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Illegitimate Values, Confirmation Bias, and Mandevillian Cognition in Science [PDF]

, 2021
In the philosophy of science, it is a common proposal that values are illegitimate in science and should be counteracted whenever they drive inquiry to the confirmation of predetermined conclusions.
Peters, Uwe
core  

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Wat beteken 'kanon' vandag?

HTS Teologiese Studies/Theological Studies, 1998
What does 'canon' mean at present? The notion of canon has become quite complicated. In textual criticism it is no longer possible to identiy the canon with only one form of the textual tradition.
P. M. Venter
doaj   +1 more source

Abandon Statistical Significance [PDF]

, 2018
We discuss problems the null hypothesis significance testing (NHST) paradigm poses for replication and more broadly in the biomedical and social sciences as well as how these problems remain unresolved by proposals involving modified p-value thresholds ...
Gal, David, Gelman, Andrew, McShane, Blakeley B., Robert, Christian, Tackett, Jennifer L.   +4 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Area Studies in the Social Sciences [PDF]

Prostranstvennaâ Èkonomika
In the last decades, area studies have been subject to substantial criticism by the most mainstream social sciences. Area specialists are perceived as lacking the knowledge of modern research methodology and rather following the interests of humanities ...
Alexander Mikhailovich Libman
doaj   +1 more source

(WP 2012-01) Samuels on Methodological Pluralism in Economics [PDF]

, 2012
Warren Samuels was an influential proponent of methodological pluralism in economics. This short paper discusses his understanding of methodological pluralism, and argues that it is based on three distinct components: (1) his critique of the idea that ...
Davis, John
core   +2 more sources