Results 61 to 70 of about 16,973,527 (293)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
ReligionsPaul’s letters emerged in response to concrete community crises. Beyond theological concerns and pastoral care, they document the leadership practice of the Apostle to the Nations.
Dariusz Iwański
doaj +1 more source
Ethnic reasoning in social identity of Hebrews: A social-scientific study
HTS Teologiese Studies/Theological Studies, 2017 Ethnicity reasoning offers one way of looking at social identity in the letter to the Hebrews. The context of socio-economic abuse and hardships of the audience creates a situation in which ethnicity in social identity becomes an important issue for the ...
Seth Kissi, Ernest van Eck
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Marx’s Theory of World History Explained: Basic Connotations and Contemporary Context
Contemporary Social Sciences, 2022 Marx’s theory of world history is an important part of his materialist conception of history (i.e., historical materialism). Marx and Engels summarized the evolution of social history and the laws behind it based on their observations and analyses of ...
Shuai Qian
doaj
La responsabilité sociologique : retour sur l’entreprise critique de Pierre Bourdieu
Recherches Sociologiques et Anthropologiques, 2005 Bourdieu speaks of a two-levelled societal role of the sociologist. Firstly, thanks to its scientific quality, sociological work can make things more supportable by pointing out the fundamental laws of society.
Mathieu Hilgers
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Actors and Vehicles of Architectural Criticism (12)
, 2016 Among Criticism, Design and Photography. A Literary and Photographic Way for the Criticism in Shared Works by Vittorio Savi, Aldo Rossi and Luigi Ghirri (1972-1989) Matteo Cassani Simonetti University of Bologna Shared works by the critic Vittorio Savi ...
Mapping Architectural Criticism
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Resente Matteusnavorsing in Suid-Afrika
HTS Teologiese Studies/Theological Studies, 1994 Recent Matthean-research in South Africa This article deals with recent developments in Matthean research, mostly by members of the New Testament Society of South Africa.
H. J.B. Combrink
doaj +1 more source