Results 71 to 80 of about 93,259 (298)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Scientific schools and scientific criticism [PDF]
, 2010 У статті обгрунтовано поняття критики, наукової критики та наукової школи. Виокремлено напрями аргументації та функції наукової критики. Окреслено класифікацію дослідників, що базуються на врахуванні мети критики.The article substantiates the concept of ...
Ничкало, Нелля Григорівна
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Mental health attitudes, self-criticism, compassion and role identity among UK social work students.
, 2018 Although many social work students suffer from mental health symptoms, the majority of them do not seek help, because of shame. Accordingly, the purposes of this study were to evaluate social work students' attitudes for mental health problems, and ...
Sheffield, David +2 more
core +1 more source
Verbum et Ecclesia, 2001 The life of modern people evolves around economics and all that goes with it, such as labour, production, consumption and possessions. These things do not only motivate many peoples' behaviour, but claim most of their energy and time. Therefore, the organising principle of life of people today is instrumental mastery - the individual's ability to ...
openaire +3 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Criticism and Counter-Criticism of Public Management: Strategy Models [PDF]
Critical control is very important in scientific management. This paper presents models of critical and counter-critical public-management strategies, focusing on the types of criticism and counter-criticism manifested in parliamentary political debates.
Luis C. Ortigueira
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HTS Teologiese Studies/Theological Studies, 2013 This article presents a social-scientific and realistic interpretation of the parable of the Feast. The characteristics of a pre-industrial city are used to determine the realism of the parable.
Ernest van Eck
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Job offer: postdoctoral Fellow
, 2017 Project Title: Architectural Criticism, an intellectual and material cartography Research Fields: Architectural History, Architectural Criticism Work Place: Rennes Research Laboratory: Research Team Histoire et Critique des Arts (EA 1279) UBL ...
Mapping Architectural Criticism
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