Results 71 to 80 of about 33,067 (254)
Of scheme paradigmatic for matrix epistemological: systematizing new levels of analysis [PDF]
ETD: Educação Temática Digital, 2014 At the moment there is a significant increase in scientific production sciences share (education, physical education and especial education) in terms of quantity, its quality becomes questionable.
Silva, Régis Henrique dos Reis +1 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Mission, identity and ethics in Mark: Jesus, the patron for outsiders
HTS Teologiese Studies/Theological Studies, 2013 In this contribution the relationship between mission, identity and ethics in Mark was investigated by means of a postcolonial and social-scientific reading, with a focus on patronage as a practice that constituted the main bond of human society in the ...
Ernest van Eck
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Fafnir, 2023 This article examines the presence and potential applications of care, empathy, and anti-binary approaches in relation to scientific thought and practice in Naomi Mitchison’s first science fiction novel, Memoirs of a Spacewoman (1962).
Grace Borland Sinclair
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The Polish Current of Criticism of Fascism in the Years 1918-1939. Bibliography of Sources
Biografistyka PedagogicznaThe aim of the article is to show the existence of a Polish current of scientific - mainly political, but also co-occurring with philosophical, theological and pedagogical - criticism of fascism and the selection of its sources.
Janina Kostkiewicz
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