Results 71 to 80 of about 624,383 (304)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Ethnic reasoning in social identity of Hebrews: A social-scientific study

HTS Teologiese Studies/Theological Studies, 2017
Ethnicity reasoning offers one way of looking at social identity in the letter to the Hebrews. The context of socio-economic abuse and hardships of the audience creates a situation in which ethnicity in social identity becomes an important issue for the ...
Seth Kissi, Ernest van Eck
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

La responsabilité sociologique : retour sur l’entreprise critique de Pierre Bourdieu

Recherches Sociologiques et Anthropologiques, 2005
Bourdieu speaks of a two-levelled societal role of the sociologist. Firstly, thanks to its scientific quality, sociological work can make things more supportable by pointing out the fundamental laws of society.
Mathieu Hilgers
doaj   +1 more source

Philosophers and Scientists Are Social Epistemic Agents [PDF]

, 2018
In this paper, I reply to Markus Arnold’s comment and Amanda Bryant’s comment on my work “Can Kuhn’s Taxonomic Incommensurability be an Image of Science?” in Moti Mizrahi’s edited collection, The Kuhnian Image of Science: Time for a ...
Park, Seungbae
core   +1 more source

Why critical realism fails to justify critical social research [PDF]

, 2009
Many social scientists have argued that research should be designed to perform a ‘critical’ function, in the sense of challenging the socio-political status quo.
Hammersley, Martyn
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Marx’s Theory of World History Explained: Basic Connotations and Contemporary Context

Contemporary Social Sciences, 2022
Marx’s theory of world history is an important part of his materialist conception of history (i.e., historical materialism). Marx and Engels summarized the evolution of social history and the laws behind it based on their observations and analyses of ...
Shuai Qian
doaj  

Resente Matteusnavorsing in Suid-Afrika

HTS Teologiese Studies/Theological Studies, 1994
Recent Matthean-research in South Africa This article deals with recent developments in Matthean research, mostly by members of the New Testament Society of South Africa.
H. J.B. Combrink
doaj   +1 more source